BK-VIRUS INFECTIONS IN PEDIATRIC LEUKEMIA PATIENTS DURING LEUKEMIA TREATMENT
Objective: Polyoma BK virus (BKV) infection/reactivation is an important underlying condition that provokes hemorrhagic cystitis (HC) in hematopoietic stem cell transplantation (HSCT) recipients. However, BKV associated infections can rarely occur in acute leukemia patients without receiving HSCT. H...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
|
| Series: | Hematology, Transfusion and Cell Therapy |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137923002183 |
| _version_ | 1827797218169454592 |
|---|---|
| author | Dilek Kaçar Zeliha Güzelküçük Ayça Koca Yozgat Melek Işık Neşe Yaralı |
| author_facet | Dilek Kaçar Zeliha Güzelküçük Ayça Koca Yozgat Melek Işık Neşe Yaralı |
| author_sort | Dilek Kaçar |
| collection | DOAJ |
| description | Objective: Polyoma BK virus (BKV) infection/reactivation is an important underlying condition that provokes hemorrhagic cystitis (HC) in hematopoietic stem cell transplantation (HSCT) recipients. However, BKV associated infections can rarely occur in acute leukemia patients without receiving HSCT. Here we present 12 pediatric acute leukemia patients with BKV infection during leukemia treatment. Methodology: Between September 2019 and July 2023, in Ankara Bilkent City Hospital, BKV by quantitative polymerase chain reaction (PCR) detected in the urine of 12 pediatric leukemia patients who had not got HSCT but receiving intensive chemotherapy. The clinical characteristics of these infections were retrospectively evaluated. Results: Ten of the 12 patients had acute lymphoblastic leukemia (ALL). Seven of the 10 ALL cases were T cell ALL. Ten of the patients were male and 10 of the patients’ age were 10 years and older. Eleven patients experienced HC and one patient had epididymitis. The copy number of BKV varied between 470 to 1.3 trillion /mL. Seven patients had got treatment ranging from hydration, ciprofloxacin to bladder irrigation. Except a refractory T cell ALL patient, all of the patients had clinical improvement. Conclusion: Although it is a major complication of HSCT and solid organ transplantation, BK virus infection can also occur in pediatric acute leukemia patients during treatment. As in HSCT recipients, male gender and older age seems as risk factors in leukemia patients. Due to complete loss of virus specific T lymphocytes, T cell ALL patients may be more prone BK virus activation. |
| first_indexed | 2024-03-11T19:19:05Z |
| format | Article |
| id | doaj.art-5f6d7764b94f4fb083f9693e9b85554e |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-03-11T19:19:05Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-5f6d7764b94f4fb083f9693e9b85554e2023-10-08T04:35:48ZengElsevierHematology, Transfusion and Cell Therapy2531-13792023-10-0145S25BK-VIRUS INFECTIONS IN PEDIATRIC LEUKEMIA PATIENTS DURING LEUKEMIA TREATMENTDilek Kaçar0Zeliha Güzelküçük1Ayça Koca Yozgat2Melek Işık3Neşe Yaralı4Ankara Bilkent City HospitalAnkara Bilkent City HospitalAnkara Bilkent City HospitalAnkara Bilkent City HospitalAnkara Bilkent City HospitalObjective: Polyoma BK virus (BKV) infection/reactivation is an important underlying condition that provokes hemorrhagic cystitis (HC) in hematopoietic stem cell transplantation (HSCT) recipients. However, BKV associated infections can rarely occur in acute leukemia patients without receiving HSCT. Here we present 12 pediatric acute leukemia patients with BKV infection during leukemia treatment. Methodology: Between September 2019 and July 2023, in Ankara Bilkent City Hospital, BKV by quantitative polymerase chain reaction (PCR) detected in the urine of 12 pediatric leukemia patients who had not got HSCT but receiving intensive chemotherapy. The clinical characteristics of these infections were retrospectively evaluated. Results: Ten of the 12 patients had acute lymphoblastic leukemia (ALL). Seven of the 10 ALL cases were T cell ALL. Ten of the patients were male and 10 of the patients’ age were 10 years and older. Eleven patients experienced HC and one patient had epididymitis. The copy number of BKV varied between 470 to 1.3 trillion /mL. Seven patients had got treatment ranging from hydration, ciprofloxacin to bladder irrigation. Except a refractory T cell ALL patient, all of the patients had clinical improvement. Conclusion: Although it is a major complication of HSCT and solid organ transplantation, BK virus infection can also occur in pediatric acute leukemia patients during treatment. As in HSCT recipients, male gender and older age seems as risk factors in leukemia patients. Due to complete loss of virus specific T lymphocytes, T cell ALL patients may be more prone BK virus activation.http://www.sciencedirect.com/science/article/pii/S2531137923002183 |
| spellingShingle | Dilek Kaçar Zeliha Güzelküçük Ayça Koca Yozgat Melek Işık Neşe Yaralı BK-VIRUS INFECTIONS IN PEDIATRIC LEUKEMIA PATIENTS DURING LEUKEMIA TREATMENT Hematology, Transfusion and Cell Therapy |
| title | BK-VIRUS INFECTIONS IN PEDIATRIC LEUKEMIA PATIENTS DURING LEUKEMIA TREATMENT |
| title_full | BK-VIRUS INFECTIONS IN PEDIATRIC LEUKEMIA PATIENTS DURING LEUKEMIA TREATMENT |
| title_fullStr | BK-VIRUS INFECTIONS IN PEDIATRIC LEUKEMIA PATIENTS DURING LEUKEMIA TREATMENT |
| title_full_unstemmed | BK-VIRUS INFECTIONS IN PEDIATRIC LEUKEMIA PATIENTS DURING LEUKEMIA TREATMENT |
| title_short | BK-VIRUS INFECTIONS IN PEDIATRIC LEUKEMIA PATIENTS DURING LEUKEMIA TREATMENT |
| title_sort | bk virus infections in pediatric leukemia patients during leukemia treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2531137923002183 |
| work_keys_str_mv | AT dilekkacar bkvirusinfectionsinpediatricleukemiapatientsduringleukemiatreatment AT zelihaguzelkucuk bkvirusinfectionsinpediatricleukemiapatientsduringleukemiatreatment AT aycakocayozgat bkvirusinfectionsinpediatricleukemiapatientsduringleukemiatreatment AT melekisık bkvirusinfectionsinpediatricleukemiapatientsduringleukemiatreatment AT neseyaralı bkvirusinfectionsinpediatricleukemiapatientsduringleukemiatreatment |