Resistance to Rhabdoviridae Infection and Subversion of Antiviral Responses
Interferon (IFN) treatment induces the expression of hundreds of IFN-stimulated genes (ISGs). However, only a selection of their products have been demonstrated to be responsible for the inhibition of rhabdovirus replication in cultured cells; and only a few have been shown to play a role in mediati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-07-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/7/7/2794 |
| _version_ | 1819054644121305088 |
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| author | Danielle Blondel Ghizlane Maarifi Sébastien Nisole Mounira K. Chelbi-Alix |
| author_facet | Danielle Blondel Ghizlane Maarifi Sébastien Nisole Mounira K. Chelbi-Alix |
| author_sort | Danielle Blondel |
| collection | DOAJ |
| description | Interferon (IFN) treatment induces the expression of hundreds of IFN-stimulated genes (ISGs). However, only a selection of their products have been demonstrated to be responsible for the inhibition of rhabdovirus replication in cultured cells; and only a few have been shown to play a role in mediating the antiviral response in vivo using gene knockout mouse models. IFNs inhibit rhabdovirus replication at different stages via the induction of a variety of ISGs. This review will discuss how individual ISG products confer resistance to rhabdoviruses by blocking viral entry, degrading single stranded viral RNA, inhibiting viral translation or preventing release of virions from the cell. Furthermore, this review will highlight how these viruses counteract the host IFN system. |
| first_indexed | 2024-12-21T12:54:54Z |
| format | Article |
| id | doaj.art-5f6de208213a4911bd16a3d8781747df |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-21T12:54:54Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-5f6de208213a4911bd16a3d8781747df2022-12-21T19:03:22ZengMDPI AGViruses1999-49152015-07-01773675370210.3390/v7072794v7072794Resistance to Rhabdoviridae Infection and Subversion of Antiviral ResponsesDanielle Blondel0Ghizlane Maarifi1Sébastien Nisole2Mounira K. Chelbi-Alix3Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS UMR 9198, Université Paris-Sud, Gif-sur-Yvette 91190, FranceINSERM UMR-S 1124, Université Paris Descartes, Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS), 75270 Paris Cedex 6, FranceINSERM UMR-S 1124, Université Paris Descartes, Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS), 75270 Paris Cedex 6, FranceINSERM UMR-S 1124, Université Paris Descartes, Centre Interdisciplinaire Chimie Biologie-Paris (FR 3567, CNRS), 75270 Paris Cedex 6, FranceInterferon (IFN) treatment induces the expression of hundreds of IFN-stimulated genes (ISGs). However, only a selection of their products have been demonstrated to be responsible for the inhibition of rhabdovirus replication in cultured cells; and only a few have been shown to play a role in mediating the antiviral response in vivo using gene knockout mouse models. IFNs inhibit rhabdovirus replication at different stages via the induction of a variety of ISGs. This review will discuss how individual ISG products confer resistance to rhabdoviruses by blocking viral entry, degrading single stranded viral RNA, inhibiting viral translation or preventing release of virions from the cell. Furthermore, this review will highlight how these viruses counteract the host IFN system.http://www.mdpi.com/1999-4915/7/7/2794interferonrhabdovirusesISGrabies virusvesicular stomatitis virus |
| spellingShingle | Danielle Blondel Ghizlane Maarifi Sébastien Nisole Mounira K. Chelbi-Alix Resistance to Rhabdoviridae Infection and Subversion of Antiviral Responses Viruses interferon rhabdoviruses ISG rabies virus vesicular stomatitis virus |
| title | Resistance to Rhabdoviridae Infection and Subversion of Antiviral Responses |
| title_full | Resistance to Rhabdoviridae Infection and Subversion of Antiviral Responses |
| title_fullStr | Resistance to Rhabdoviridae Infection and Subversion of Antiviral Responses |
| title_full_unstemmed | Resistance to Rhabdoviridae Infection and Subversion of Antiviral Responses |
| title_short | Resistance to Rhabdoviridae Infection and Subversion of Antiviral Responses |
| title_sort | resistance to rhabdoviridae infection and subversion of antiviral responses |
| topic | interferon rhabdoviruses ISG rabies virus vesicular stomatitis virus |
| url | http://www.mdpi.com/1999-4915/7/7/2794 |
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