Multifunctional nanoparticles for targeted delivery of apoptin plasmid in cancer treatment
The systemic toxicity and low efficacy of traditional chemotherapy for hepatocellular carcinoma (HCC) result in poor clinical outcomes. This study was designed to achieve targeted delivery of apoptin plasmid (AP) to liver tumors and killing of cancer cells using multifunctional nanoparticles (MFNPs)...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-03-01
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| Series: | e-Polymers |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/epoly-2022-0020 |
| _version_ | 1811203712913244160 |
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| author | He Zhuanxia Bao Ke Zhang Jiawei Ju Dandan Luo Mingyan Liu Liyan Gao Xiujun |
| author_facet | He Zhuanxia Bao Ke Zhang Jiawei Ju Dandan Luo Mingyan Liu Liyan Gao Xiujun |
| author_sort | He Zhuanxia |
| collection | DOAJ |
| description | The systemic toxicity and low efficacy of traditional chemotherapy for hepatocellular carcinoma (HCC) result in poor clinical outcomes. This study was designed to achieve targeted delivery of apoptin plasmid (AP) to liver tumors and killing of cancer cells using multifunctional nanoparticles (MFNPs) having sustained-release properties. The MFNPs featuring a distinct core-shell structure were prepared using poly(lactic-glycolic acid)-ε-polylysine copolymer and loaded with AP by adsorption. Specific targeting of liver tumor cells was achieved by biotinylation of the nanoparticles (NPs), while an improvement in lysosomal escape and nuclear localization enhanced the tumor cell killing capability of AP. Blank MFNPs exhibited good biocompatibility while AP-loaded NPs were found to exert strong inhibitory effects on both tumor cells in vitro and solid tumors in vivo. Taken together, these findings demonstrate a promising route for the development of tumor-targeted NPs which may lead to improved therapeutic strategies for treating HCC. |
| first_indexed | 2024-04-12T02:59:28Z |
| format | Article |
| id | doaj.art-5f7142c923c24e838619845b0447bcc1 |
| institution | Directory Open Access Journal |
| issn | 1618-7229 |
| language | English |
| last_indexed | 2024-04-12T02:59:28Z |
| publishDate | 2022-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | e-Polymers |
| spelling | doaj.art-5f7142c923c24e838619845b0447bcc12022-12-22T03:50:42ZengDe Gruytere-Polymers1618-72292022-03-0122134235610.1515/epoly-2022-0020Multifunctional nanoparticles for targeted delivery of apoptin plasmid in cancer treatmentHe Zhuanxia0Bao Ke1Zhang Jiawei2Ju Dandan3Luo Mingyan4Liu Liyan5Gao Xiujun6School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, ChinaSchool of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, ChinaSchool of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, ChinaSchool of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, ChinaSchool of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, ChinaCollege of Science, Civil Aviation University of China, Tianjin 300300, ChinaSchool of Biomedical Engineering and Technology, Tianjin Medical University, No. 22, Meteorological Station Road, Tianjin 300070, ChinaThe systemic toxicity and low efficacy of traditional chemotherapy for hepatocellular carcinoma (HCC) result in poor clinical outcomes. This study was designed to achieve targeted delivery of apoptin plasmid (AP) to liver tumors and killing of cancer cells using multifunctional nanoparticles (MFNPs) having sustained-release properties. The MFNPs featuring a distinct core-shell structure were prepared using poly(lactic-glycolic acid)-ε-polylysine copolymer and loaded with AP by adsorption. Specific targeting of liver tumor cells was achieved by biotinylation of the nanoparticles (NPs), while an improvement in lysosomal escape and nuclear localization enhanced the tumor cell killing capability of AP. Blank MFNPs exhibited good biocompatibility while AP-loaded NPs were found to exert strong inhibitory effects on both tumor cells in vitro and solid tumors in vivo. Taken together, these findings demonstrate a promising route for the development of tumor-targeted NPs which may lead to improved therapeutic strategies for treating HCC.https://doi.org/10.1515/epoly-2022-0020multifunctional nanoparticlestargeted deliveryapoptin plasmidhepatocellular carcinoma |
| spellingShingle | He Zhuanxia Bao Ke Zhang Jiawei Ju Dandan Luo Mingyan Liu Liyan Gao Xiujun Multifunctional nanoparticles for targeted delivery of apoptin plasmid in cancer treatment e-Polymers multifunctional nanoparticles targeted delivery apoptin plasmid hepatocellular carcinoma |
| title | Multifunctional nanoparticles for targeted delivery of apoptin plasmid in cancer treatment |
| title_full | Multifunctional nanoparticles for targeted delivery of apoptin plasmid in cancer treatment |
| title_fullStr | Multifunctional nanoparticles for targeted delivery of apoptin plasmid in cancer treatment |
| title_full_unstemmed | Multifunctional nanoparticles for targeted delivery of apoptin plasmid in cancer treatment |
| title_short | Multifunctional nanoparticles for targeted delivery of apoptin plasmid in cancer treatment |
| title_sort | multifunctional nanoparticles for targeted delivery of apoptin plasmid in cancer treatment |
| topic | multifunctional nanoparticles targeted delivery apoptin plasmid hepatocellular carcinoma |
| url | https://doi.org/10.1515/epoly-2022-0020 |
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