The Synthesis of Glycyrrhetinic Acid Derivatives Containing A Nitrogen Heterocycle and Their Antiproliferative Effects in Human Leukemia Cells

The Synthesis of Glycyrrhetinic Acid Derivatives Containing A Nitrogen Heterocycle and Their Antiproliferative Effects in Human Leukemia Cells

Fifteen novel glycyrrhetinic acid derivatives containing a nitrogen heterocycle at C-30 and with different A-ring substituents were designed and synthesized. All of these derivatives have improved antiproliferative effects against human HL-60 leukemia cells. Compounds with a cyano-enone functionalit...

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Bibliographic Details
Main Authors: Yuan Gao, Xin Guo, Xiaojing Li, Dan Liu, Dandan Song, Ye Xu, Ming Sun, Yongkui Jing, Linxiang Zhao
Format: Article
Language:English
Published: MDPI AG 2010-06-01
Series:Molecules
Subjects:
antiproliferative
glycyrrhetinic acid derivative
leukemia
nitrogen heterocycle
Online Access:http://www.mdpi.com/1420-3049/15/6/4439/

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