Targeted Antibiotics for Lower Respiratory Tract Infection with Corynebacterium striatum
Huan Zhang,1,2 Xiaojiao Tan,1 Zhen Zhang,1 Xuewei Yang,1 Lijie Wang,1 Meiqian Li,1 Dan Shi,1 Yao Li,1 Jianbo Li,1 Zhen Li,3 Xuelian Liao1,4 1Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Critical Care Medicine, The...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-04-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/targeted-antibiotics-for-lower-respiratory-tract-infection-with-coryne-peer-reviewed-fulltext-article-IDR |
| _version_ | 1797852378859307008 |
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| author | Zhang H Tan X Zhang Z Yang X Wang L Li M Shi D Li Y Li J Li Z Liao X |
| author_facet | Zhang H Tan X Zhang Z Yang X Wang L Li M Shi D Li Y Li J Li Z Liao X |
| author_sort | Zhang H |
| collection | DOAJ |
| description | Huan Zhang,1,2 Xiaojiao Tan,1 Zhen Zhang,1 Xuewei Yang,1 Lijie Wang,1 Meiqian Li,1 Dan Shi,1 Yao Li,1 Jianbo Li,1 Zhen Li,3 Xuelian Liao1,4 1Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Critical Care Medicine, The Third People’s Hospital of Chengdu, Chengdu, People’s Republic of China; 3Clinical Research Unit, First Maternity and Infant Hospital of Shanghai, Shanghai, People’s Republic of China; 4Department of Critical Care Medicine, West China Tianfu Hospital of Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Xuelian Liao, Department of Critical Care Medicine, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou district, Chengdu, People’s Republic of China, Tel +8613541023033, Email liaoxuelian@scu.edu.cnPurpose: To assess the impact of targeted antibiotic therapy on clinical outcomes of patients with lower respiratory tract (LRT) infection with Corynebacterium striatum (C. striatum).Methods: A new propensity score-inverse probability of treatment weighting (IPTW) cohort study was conducted by using 10-year data. The study included LRT infection patients with respiratory secretions cultured positive for C. striatum simultaneously. The primary outcome was all-cause hospital mortality; the secondary outcomes included hospital stay, ICU stay and ventilation time. The safety outcomes were drug-related serum creatinine (Cr) increase and thrombocytopenia.Results: A total of 339 patients were included in the cohort, and 84 (24.78%) initiated vancomycin or linezolid therapy. In the new IPTW cohort, targeted antibiotic therapy did not improve all-cause hospital mortality (P=0.632), and the OR (95% CI) was 0.879 (0.519– 1.488). Moreover, targeted antibiotic therapy was not associated with hospital stay (P=0.415), ICU stay (P=0.945) or ventilation time (P=0.885). The side effects of drug-related higher serum Cr (P=0.044) and thrombocytopenic levels (P=0.038) cannot be ignored.Conclusion: Clinical benefits by vancomycin or linezolid targeted against LRT infection with C. striatum were limited and with drug-related side effects. A prospectively designed study is needed to further confirm the results.Keywords: Corynebacterium striatum, lower respiratory tract infection, vancomycin, linezolid, all-cause mortality |
| first_indexed | 2024-04-09T19:33:22Z |
| format | Article |
| id | doaj.art-5f72912ad94446febe09e88ec46b029b |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-09T19:33:22Z |
| publishDate | 2023-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-5f72912ad94446febe09e88ec46b029b2023-04-04T20:11:33ZengDove Medical PressInfection and Drug Resistance1178-69732023-04-01Volume 162019202882766Targeted Antibiotics for Lower Respiratory Tract Infection with Corynebacterium striatumZhang HTan XZhang ZYang XWang LLi MShi DLi YLi JLi ZLiao XHuan Zhang,1,2 Xiaojiao Tan,1 Zhen Zhang,1 Xuewei Yang,1 Lijie Wang,1 Meiqian Li,1 Dan Shi,1 Yao Li,1 Jianbo Li,1 Zhen Li,3 Xuelian Liao1,4 1Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Critical Care Medicine, The Third People’s Hospital of Chengdu, Chengdu, People’s Republic of China; 3Clinical Research Unit, First Maternity and Infant Hospital of Shanghai, Shanghai, People’s Republic of China; 4Department of Critical Care Medicine, West China Tianfu Hospital of Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Xuelian Liao, Department of Critical Care Medicine, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou district, Chengdu, People’s Republic of China, Tel +8613541023033, Email liaoxuelian@scu.edu.cnPurpose: To assess the impact of targeted antibiotic therapy on clinical outcomes of patients with lower respiratory tract (LRT) infection with Corynebacterium striatum (C. striatum).Methods: A new propensity score-inverse probability of treatment weighting (IPTW) cohort study was conducted by using 10-year data. The study included LRT infection patients with respiratory secretions cultured positive for C. striatum simultaneously. The primary outcome was all-cause hospital mortality; the secondary outcomes included hospital stay, ICU stay and ventilation time. The safety outcomes were drug-related serum creatinine (Cr) increase and thrombocytopenia.Results: A total of 339 patients were included in the cohort, and 84 (24.78%) initiated vancomycin or linezolid therapy. In the new IPTW cohort, targeted antibiotic therapy did not improve all-cause hospital mortality (P=0.632), and the OR (95% CI) was 0.879 (0.519– 1.488). Moreover, targeted antibiotic therapy was not associated with hospital stay (P=0.415), ICU stay (P=0.945) or ventilation time (P=0.885). The side effects of drug-related higher serum Cr (P=0.044) and thrombocytopenic levels (P=0.038) cannot be ignored.Conclusion: Clinical benefits by vancomycin or linezolid targeted against LRT infection with C. striatum were limited and with drug-related side effects. A prospectively designed study is needed to further confirm the results.Keywords: Corynebacterium striatum, lower respiratory tract infection, vancomycin, linezolid, all-cause mortalityhttps://www.dovepress.com/targeted-antibiotics-for-lower-respiratory-tract-infection-with-coryne-peer-reviewed-fulltext-article-IDRcorynebacteritum striatumlower respiratory tract infectionvancomycinlinezolidall-cause mortality. |
| spellingShingle | Zhang H Tan X Zhang Z Yang X Wang L Li M Shi D Li Y Li J Li Z Liao X Targeted Antibiotics for Lower Respiratory Tract Infection with Corynebacterium striatum Infection and Drug Resistance corynebacteritum striatum lower respiratory tract infection vancomycin linezolid all-cause mortality. |
| title | Targeted Antibiotics for Lower Respiratory Tract Infection with Corynebacterium striatum |
| title_full | Targeted Antibiotics for Lower Respiratory Tract Infection with Corynebacterium striatum |
| title_fullStr | Targeted Antibiotics for Lower Respiratory Tract Infection with Corynebacterium striatum |
| title_full_unstemmed | Targeted Antibiotics for Lower Respiratory Tract Infection with Corynebacterium striatum |
| title_short | Targeted Antibiotics for Lower Respiratory Tract Infection with Corynebacterium striatum |
| title_sort | targeted antibiotics for lower respiratory tract infection with corynebacterium striatum |
| topic | corynebacteritum striatum lower respiratory tract infection vancomycin linezolid all-cause mortality. |
| url | https://www.dovepress.com/targeted-antibiotics-for-lower-respiratory-tract-infection-with-coryne-peer-reviewed-fulltext-article-IDR |
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