Perindopril effects on circadian heart rate variability in patients with coronary heart disease and stable angina
Aim. To study the effects of ACE inhibitor perindopril on circadian dynamic of heart rate variability (HRV) in patients with coronary heart disease (CHD) and stable effort angina. Material and methods. The study included 68 patients with stable effort angina, without myocardial infarction in anamnes...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2007-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1282 |
| _version_ | 1797882737769578496 |
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| author | N. A. Shardanov E. K. Arsagova L. M. Batyrbekova M. Kh. Kurdanova Kh. A. Kurdanov |
| author_facet | N. A. Shardanov E. K. Arsagova L. M. Batyrbekova M. Kh. Kurdanova Kh. A. Kurdanov |
| author_sort | N. A. Shardanov |
| collection | DOAJ |
| description | Aim. To study the effects of ACE inhibitor perindopril on circadian dynamic of heart rate variability (HRV) in patients with coronary heart disease (CHD) and stable effort angina. Material and methods. The study included 68 patients with stable effort angina, without myocardial infarction in anamnesis, as well as 30 controls. Circadian HRV was assessed by Holter monitoring method, during isosorbide dinitrate and aspirin therapy, and 31 days after adding perindopril (4-8 mg/d). Results. At baseline, temporal and spectral HRV parameters were decreased in CHD patients with stable angina, improving during perindopril therapy (4-8 mg/d). Positive dynamics was maximal for parasympathetic activity markers. Perindopril therapy also reduced ventricular extrasystole number in CHD patients. Conclusion. Perindopril (4-8 mg/d) improved circadian BP dynamics in CHD patients with stable effort angina, especially in individuals with advanced functional classes. Perindopril also demonstrated antiarrhythmic effect. |
| first_indexed | 2024-04-10T03:40:14Z |
| format | Article |
| id | doaj.art-5f73578c56134939be33c381a444c3a5 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:40:14Z |
| publishDate | 2007-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-5f73578c56134939be33c381a444c3a52023-03-13T07:23:14Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252007-08-01643740993Perindopril effects on circadian heart rate variability in patients with coronary heart disease and stable anginaN. A. Shardanov0E. K. Arsagova1L. M. Batyrbekova2M. Kh. Kurdanova3Kh. A. Kurdanov4Центр медико-экологических исследований – филиал Государственного научного центра Российской Федерации Института медико-биологических проблем РАН, НальчикЦентр медико-экологических исследований – филиал Государственного научного центра Российской Федерации Института медико-биологических проблем РАН, НальчикЦентр медико-экологических исследований – филиал Государственного научного центра Российской Федерации Института медико-биологических проблем РАН, НальчикЦентр медико-экологических исследований – филиал Государственного научного центра Российской Федерации Института медико-биологических проблем РАН, НальчикЦентр медико-экологических исследований – филиал Государственного научного центра Российской Федерации Института медико-биологических проблем РАН, НальчикAim. To study the effects of ACE inhibitor perindopril on circadian dynamic of heart rate variability (HRV) in patients with coronary heart disease (CHD) and stable effort angina. Material and methods. The study included 68 patients with stable effort angina, without myocardial infarction in anamnesis, as well as 30 controls. Circadian HRV was assessed by Holter monitoring method, during isosorbide dinitrate and aspirin therapy, and 31 days after adding perindopril (4-8 mg/d). Results. At baseline, temporal and spectral HRV parameters were decreased in CHD patients with stable angina, improving during perindopril therapy (4-8 mg/d). Positive dynamics was maximal for parasympathetic activity markers. Perindopril therapy also reduced ventricular extrasystole number in CHD patients. Conclusion. Perindopril (4-8 mg/d) improved circadian BP dynamics in CHD patients with stable effort angina, especially in individuals with advanced functional classes. Perindopril also demonstrated antiarrhythmic effect.https://cardiovascular.elpub.ru/jour/article/view/1282ишемическая болезнь сердцавариабельность сердечного ритмахолтеровское мониторированиепериндоприл |
| spellingShingle | N. A. Shardanov E. K. Arsagova L. M. Batyrbekova M. Kh. Kurdanova Kh. A. Kurdanov Perindopril effects on circadian heart rate variability in patients with coronary heart disease and stable angina Кардиоваскулярная терапия и профилактика ишемическая болезнь сердца вариабельность сердечного ритма холтеровское мониторирование периндоприл |
| title | Perindopril effects on circadian heart rate variability in patients with coronary heart disease and stable angina |
| title_full | Perindopril effects on circadian heart rate variability in patients with coronary heart disease and stable angina |
| title_fullStr | Perindopril effects on circadian heart rate variability in patients with coronary heart disease and stable angina |
| title_full_unstemmed | Perindopril effects on circadian heart rate variability in patients with coronary heart disease and stable angina |
| title_short | Perindopril effects on circadian heart rate variability in patients with coronary heart disease and stable angina |
| title_sort | perindopril effects on circadian heart rate variability in patients with coronary heart disease and stable angina |
| topic | ишемическая болезнь сердца вариабельность сердечного ритма холтеровское мониторирование периндоприл |
| url | https://cardiovascular.elpub.ru/jour/article/view/1282 |
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