Impacts of parathyroidectomy on calcium and phosphorus metabolism disorder, arterial calcification and arterial stiffness in haemodialysis patients
Summary: Background: Secondary hyperparathyroidism (SHPT) and calcium and phosphorus metabolism disorder are important complications in haemodialysis patients. Parathyroidectomy (PTX) may prevent or delay the progress of vascular calcification in haemodialysis patients. Objective: To investigate th...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Asian Journal of Surgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S101595841730489X |
| _version_ | 1819084187420852224 |
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| author | Zhuo Gao Xiaomei Li Jing Miao Lide Lun |
| author_facet | Zhuo Gao Xiaomei Li Jing Miao Lide Lun |
| author_sort | Zhuo Gao |
| collection | DOAJ |
| description | Summary: Background: Secondary hyperparathyroidism (SHPT) and calcium and phosphorus metabolism disorder are important complications in haemodialysis patients. Parathyroidectomy (PTX) may prevent or delay the progress of vascular calcification in haemodialysis patients. Objective: To investigate the impacts of PTX on calcium and phosphorus metabolism, arterial calcification and arterial stiffness in haemodialysis patients with SHPT. Methods: Twenty-one SHPT-haemodialysis patients were selected for PTX. The preoperative and postoperative 1-year scores of coronary artery calcification were measured via multislice spiral CT, along with the brachial-ankle pulse wave velocity (baPWV), and preoperative and postoperative 1-year indexes such as calcium, phosphorus, calcium-phosphorus product concentration and parathyroid hormone (PTH) level were compared. Results: Compared with the preoperative score, the postoperative 1-year coronary artery calcification score was significantly reduced; the mean baPWVs of the bilateral limbs were reduced; and the levels of serum calcium, phosphorus, calcium-phosphorus product concentration and PTH were all reduced; all differences were statistically significant (P < 0.05). Conclusions: PTX can be used to correct calcium and phosphorus metabolism disorder, reduce arterial calcification, and improve arterial stiffness. Keywords: Haemodialysis, Secondary hyperparathyroidism, Parathyroidectomy, Coronary artery calcification score, Brachial-ankle pulse wave velocity |
| first_indexed | 2024-12-21T20:44:28Z |
| format | Article |
| id | doaj.art-5f7512e4d79c4d8191562993bf8ff728 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-21T20:44:28Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-5f7512e4d79c4d8191562993bf8ff7282022-12-21T18:50:51ZengElsevierAsian Journal of Surgery1015-95842019-01-01421610Impacts of parathyroidectomy on calcium and phosphorus metabolism disorder, arterial calcification and arterial stiffness in haemodialysis patientsZhuo Gao0Xiaomei Li1Jing Miao2Lide Lun3Department of Rheumatology and Nephrology, General Hospital of Air Force, Haidian District, Beijing, 100142, ChinaDepartment of Rheumatology and Nephrology, General Hospital of Air Force, Haidian District, Beijing, 100142, ChinaDepartment of Rheumatology and Nephrology, General Hospital of Air Force, Haidian District, Beijing, 100142, ChinaCorresponding author. Department of Rheumatology and Nephrology, General Hospital of Air Force, No. 30 Fucheng Road, Haidian District, Beijing, 100142, China.; Department of Rheumatology and Nephrology, General Hospital of Air Force, Haidian District, Beijing, 100142, ChinaSummary: Background: Secondary hyperparathyroidism (SHPT) and calcium and phosphorus metabolism disorder are important complications in haemodialysis patients. Parathyroidectomy (PTX) may prevent or delay the progress of vascular calcification in haemodialysis patients. Objective: To investigate the impacts of PTX on calcium and phosphorus metabolism, arterial calcification and arterial stiffness in haemodialysis patients with SHPT. Methods: Twenty-one SHPT-haemodialysis patients were selected for PTX. The preoperative and postoperative 1-year scores of coronary artery calcification were measured via multislice spiral CT, along with the brachial-ankle pulse wave velocity (baPWV), and preoperative and postoperative 1-year indexes such as calcium, phosphorus, calcium-phosphorus product concentration and parathyroid hormone (PTH) level were compared. Results: Compared with the preoperative score, the postoperative 1-year coronary artery calcification score was significantly reduced; the mean baPWVs of the bilateral limbs were reduced; and the levels of serum calcium, phosphorus, calcium-phosphorus product concentration and PTH were all reduced; all differences were statistically significant (P < 0.05). Conclusions: PTX can be used to correct calcium and phosphorus metabolism disorder, reduce arterial calcification, and improve arterial stiffness. Keywords: Haemodialysis, Secondary hyperparathyroidism, Parathyroidectomy, Coronary artery calcification score, Brachial-ankle pulse wave velocityhttp://www.sciencedirect.com/science/article/pii/S101595841730489X |
| spellingShingle | Zhuo Gao Xiaomei Li Jing Miao Lide Lun Impacts of parathyroidectomy on calcium and phosphorus metabolism disorder, arterial calcification and arterial stiffness in haemodialysis patients Asian Journal of Surgery |
| title | Impacts of parathyroidectomy on calcium and phosphorus metabolism disorder, arterial calcification and arterial stiffness in haemodialysis patients |
| title_full | Impacts of parathyroidectomy on calcium and phosphorus metabolism disorder, arterial calcification and arterial stiffness in haemodialysis patients |
| title_fullStr | Impacts of parathyroidectomy on calcium and phosphorus metabolism disorder, arterial calcification and arterial stiffness in haemodialysis patients |
| title_full_unstemmed | Impacts of parathyroidectomy on calcium and phosphorus metabolism disorder, arterial calcification and arterial stiffness in haemodialysis patients |
| title_short | Impacts of parathyroidectomy on calcium and phosphorus metabolism disorder, arterial calcification and arterial stiffness in haemodialysis patients |
| title_sort | impacts of parathyroidectomy on calcium and phosphorus metabolism disorder arterial calcification and arterial stiffness in haemodialysis patients |
| url | http://www.sciencedirect.com/science/article/pii/S101595841730489X |
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