The effects of omega-3 fatty acid supplementation on serum myostatin, body composition, blood glucose, lipid profile and hs-CRP level in overweight men with coronary heart disease: A randomized double-blind placebo controlled clinical trial
Background: Cardiovascular diseases, including heart cachexia, are considered as one of the most critical issues in health care that could be affected by several factors, such as myostatin whose critical role has been confirmed in the progress of heart cachexia and cardiac muscle dysfunction. This s...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Human Nutrition & Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666149724000100 |
| _version_ | 1797323768523128832 |
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| author | Mohammad sharifzadeh Leila setayesh Mohammad Reza Emami Shirin Jafari Salim Mo hammad Hassan Javanbakht |
| author_facet | Mohammad sharifzadeh Leila setayesh Mohammad Reza Emami Shirin Jafari Salim Mo hammad Hassan Javanbakht |
| author_sort | Mohammad sharifzadeh |
| collection | DOAJ |
| description | Background: Cardiovascular diseases, including heart cachexia, are considered as one of the most critical issues in health care that could be affected by several factors, such as myostatin whose critical role has been confirmed in the progress of heart cachexia and cardiac muscle dysfunction. This study was conducted to clarify the precise role of omega-3 polyunsaturated fatty acid (ω-3PUFA) on lipid profile, blood glucose, body composition, and serum level of myostatin in individuals with coronary artery disease (CAD). Materials and methods: Forty-two adult males (aged 45–65 years) with CAD had been confirmed by angiography were randomly divided into two groups, group 1 received omega-3 (1200mg daily) and group 2 received placebo (paraffin) for 8 weeks. The serum level of myostatin was measured using an ELISA kit in the beginning and at the end of the intervention. Moreover, body composition and anthropometric measurements of the patients were also evaluated. Result: A significant difference was observed in the myostatin level after 8weeks of intervention with omega3 supplement between omega3 and placebo group (p = 0.02).There was a significant difference in high-sensitivity C-reactive protein(hsCRP) concentration (p = 0.02) and low-density lipoprotein cholesterol (p = 0.01) between intervention group and control group at the end of the intervention. However, no statistically significant changes were seen in the body composition, anthropometric parameters, fasting insulin level, and fasting blood sugar within and between the groups. Conclusion: Omega-3 oral supplementation may improve the status of CAD patients by decreasing the level of myostatin, LDL-C and hs-CRP. |
| first_indexed | 2024-03-08T05:33:56Z |
| format | Article |
| id | doaj.art-5f763bc5720344389b700c008b5b2a5c |
| institution | Directory Open Access Journal |
| issn | 2666-1497 |
| language | English |
| last_indexed | 2024-03-08T05:33:56Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Nutrition & Metabolism |
| spelling | doaj.art-5f763bc5720344389b700c008b5b2a5c2024-02-06T04:12:49ZengElsevierHuman Nutrition & Metabolism2666-14972024-06-0136200248The effects of omega-3 fatty acid supplementation on serum myostatin, body composition, blood glucose, lipid profile and hs-CRP level in overweight men with coronary heart disease: A randomized double-blind placebo controlled clinical trialMohammad sharifzadeh0Leila setayesh1Mohammad Reza Emami2Shirin Jafari Salim3Mo hammad Hassan Javanbakht4Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, IranDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, IranDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Corresponding author. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), 14155-6446, Tehran, Iran.Background: Cardiovascular diseases, including heart cachexia, are considered as one of the most critical issues in health care that could be affected by several factors, such as myostatin whose critical role has been confirmed in the progress of heart cachexia and cardiac muscle dysfunction. This study was conducted to clarify the precise role of omega-3 polyunsaturated fatty acid (ω-3PUFA) on lipid profile, blood glucose, body composition, and serum level of myostatin in individuals with coronary artery disease (CAD). Materials and methods: Forty-two adult males (aged 45–65 years) with CAD had been confirmed by angiography were randomly divided into two groups, group 1 received omega-3 (1200mg daily) and group 2 received placebo (paraffin) for 8 weeks. The serum level of myostatin was measured using an ELISA kit in the beginning and at the end of the intervention. Moreover, body composition and anthropometric measurements of the patients were also evaluated. Result: A significant difference was observed in the myostatin level after 8weeks of intervention with omega3 supplement between omega3 and placebo group (p = 0.02).There was a significant difference in high-sensitivity C-reactive protein(hsCRP) concentration (p = 0.02) and low-density lipoprotein cholesterol (p = 0.01) between intervention group and control group at the end of the intervention. However, no statistically significant changes were seen in the body composition, anthropometric parameters, fasting insulin level, and fasting blood sugar within and between the groups. Conclusion: Omega-3 oral supplementation may improve the status of CAD patients by decreasing the level of myostatin, LDL-C and hs-CRP.http://www.sciencedirect.com/science/article/pii/S2666149724000100Coronary artery diseaseMyostatinBody compositionOmega-3 polyunsaturated fatty acid |
| spellingShingle | Mohammad sharifzadeh Leila setayesh Mohammad Reza Emami Shirin Jafari Salim Mo hammad Hassan Javanbakht The effects of omega-3 fatty acid supplementation on serum myostatin, body composition, blood glucose, lipid profile and hs-CRP level in overweight men with coronary heart disease: A randomized double-blind placebo controlled clinical trial Human Nutrition & Metabolism Coronary artery disease Myostatin Body composition Omega-3 polyunsaturated fatty acid |
| title | The effects of omega-3 fatty acid supplementation on serum myostatin, body composition, blood glucose, lipid profile and hs-CRP level in overweight men with coronary heart disease: A randomized double-blind placebo controlled clinical trial |
| title_full | The effects of omega-3 fatty acid supplementation on serum myostatin, body composition, blood glucose, lipid profile and hs-CRP level in overweight men with coronary heart disease: A randomized double-blind placebo controlled clinical trial |
| title_fullStr | The effects of omega-3 fatty acid supplementation on serum myostatin, body composition, blood glucose, lipid profile and hs-CRP level in overweight men with coronary heart disease: A randomized double-blind placebo controlled clinical trial |
| title_full_unstemmed | The effects of omega-3 fatty acid supplementation on serum myostatin, body composition, blood glucose, lipid profile and hs-CRP level in overweight men with coronary heart disease: A randomized double-blind placebo controlled clinical trial |
| title_short | The effects of omega-3 fatty acid supplementation on serum myostatin, body composition, blood glucose, lipid profile and hs-CRP level in overweight men with coronary heart disease: A randomized double-blind placebo controlled clinical trial |
| title_sort | effects of omega 3 fatty acid supplementation on serum myostatin body composition blood glucose lipid profile and hs crp level in overweight men with coronary heart disease a randomized double blind placebo controlled clinical trial |
| topic | Coronary artery disease Myostatin Body composition Omega-3 polyunsaturated fatty acid |
| url | http://www.sciencedirect.com/science/article/pii/S2666149724000100 |
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