Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment
Steroid-induced osteonecrosis of the femoral head (SONFH) is a disease characterized by the collapse of the femoral head. SONFH occurs due to the overuse of glucocorticoids (GCs) in patients with immune-related diseases. Among various pathogenesis proposed, the mechanism related to impaired blood ve...
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.777697/full |
| _version_ | 1831570362103496704 |
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| author | Cheng Huang Zeqin Wen Junjie Niu Subin Lin Weiguo Wang |
| author_facet | Cheng Huang Zeqin Wen Junjie Niu Subin Lin Weiguo Wang |
| author_sort | Cheng Huang |
| collection | DOAJ |
| description | Steroid-induced osteonecrosis of the femoral head (SONFH) is a disease characterized by the collapse of the femoral head. SONFH occurs due to the overuse of glucocorticoids (GCs) in patients with immune-related diseases. Among various pathogenesis proposed, the mechanism related to impaired blood vessels is gradually becoming the most convincing hypothesis. Bone endothelial cells including bone microvascular endothelial cells (BMECs) and endothelial progenitor cells (EPCs) play a crucial role in the maintenance of vascular homeostasis. Therefore, bone endothelial cells are key regulators in the occurrence and progression of SONFH. Impaired angiogenesis, abnormal apoptosis, thrombosis and fat embolism caused by the dysfunctions of bone endothelial cells are considered to be the pathogenesis of SONFH. In addition, even with high disability rates, SONFH lacks effective therapeutic approach. Icariin (ICA, a flavonoid extracted from Epimedii Herba), pravastatin, and VO-OHpic (a potent inhibitor of PTEN) are candidate reagents to prevent and treat SONFH through improving above pathological processes. However, these reagents are still in the preclinical stage and will not be widely used temporarily. In this case, bone tissue engineering represented by co-transplantation of bone endothelial cells and bone marrow mesenchymal stem cells (BMSCs) may be another feasible therapeutic strategy. |
| first_indexed | 2024-12-17T12:50:09Z |
| format | Article |
| id | doaj.art-5f779a1fa83d4eeab4e5c3b27d727a5b |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-17T12:50:09Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-5f779a1fa83d4eeab4e5c3b27d727a5b2022-12-21T21:47:37ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-11-01910.3389/fcell.2021.777697777697Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and TreatmentCheng Huang0Zeqin Wen1Junjie Niu2Subin Lin3Weiguo Wang4Department of Orthopedics, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Orthopedics, China-Japan Friendship Hospital, Beijing, ChinaSteroid-induced osteonecrosis of the femoral head (SONFH) is a disease characterized by the collapse of the femoral head. SONFH occurs due to the overuse of glucocorticoids (GCs) in patients with immune-related diseases. Among various pathogenesis proposed, the mechanism related to impaired blood vessels is gradually becoming the most convincing hypothesis. Bone endothelial cells including bone microvascular endothelial cells (BMECs) and endothelial progenitor cells (EPCs) play a crucial role in the maintenance of vascular homeostasis. Therefore, bone endothelial cells are key regulators in the occurrence and progression of SONFH. Impaired angiogenesis, abnormal apoptosis, thrombosis and fat embolism caused by the dysfunctions of bone endothelial cells are considered to be the pathogenesis of SONFH. In addition, even with high disability rates, SONFH lacks effective therapeutic approach. Icariin (ICA, a flavonoid extracted from Epimedii Herba), pravastatin, and VO-OHpic (a potent inhibitor of PTEN) are candidate reagents to prevent and treat SONFH through improving above pathological processes. However, these reagents are still in the preclinical stage and will not be widely used temporarily. In this case, bone tissue engineering represented by co-transplantation of bone endothelial cells and bone marrow mesenchymal stem cells (BMSCs) may be another feasible therapeutic strategy.https://www.frontiersin.org/articles/10.3389/fcell.2021.777697/fullsteroid-induced osteonecrosis of the femoral headbone endothelial cellsbone microvascular endothelial cellsbone progenitor cellsangiogenesispathogenesis |
| spellingShingle | Cheng Huang Zeqin Wen Junjie Niu Subin Lin Weiguo Wang Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment Frontiers in Cell and Developmental Biology steroid-induced osteonecrosis of the femoral head bone endothelial cells bone microvascular endothelial cells bone progenitor cells angiogenesis pathogenesis |
| title | Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment |
| title_full | Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment |
| title_fullStr | Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment |
| title_full_unstemmed | Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment |
| title_short | Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment |
| title_sort | steroid induced osteonecrosis of the femoral head novel insight into the roles of bone endothelial cells in pathogenesis and treatment |
| topic | steroid-induced osteonecrosis of the femoral head bone endothelial cells bone microvascular endothelial cells bone progenitor cells angiogenesis pathogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.777697/full |
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