Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording
During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices. Among them, the combination of optogenetics and electrophysiology...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/12/6/725 |
| _version_ | 1827689284499406848 |
|---|---|
| author | Saeyeong Jeon Youjin Lee Daeho Ryu Yoon Kyung Cho Yena Lee Sang Beom Jun Chang-Hyeon Ji |
| author_facet | Saeyeong Jeon Youjin Lee Daeho Ryu Yoon Kyung Cho Yena Lee Sang Beom Jun Chang-Hyeon Ji |
| author_sort | Saeyeong Jeon |
| collection | DOAJ |
| description | During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices. Among them, the combination of optogenetics and electrophysiology provides an opportunity for facilitating optogenetic approaches. In this study, a novel design of an optrode array was proposed for realizing optical modulation and electrophysiological recording. A 4 × 4 optrode array and five-channel recording electrodes were assembled as a disposable part, while a reusable part comprised an LED (light-emitting diode) source and a power line. After the characterization of the intensity of the light delivered at the fiber tips, in vivo animal experiment was performed with transgenic mice expressing channelrhodopsin, showing the effectiveness of optical activation and neural recording. |
| first_indexed | 2024-03-10T10:14:38Z |
| format | Article |
| id | doaj.art-5f77ff99b5fd41219239c6adfa0cd39e |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T10:14:38Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-5f77ff99b5fd41219239c6adfa0cd39e2023-11-22T00:53:41ZengMDPI AGMicromachines2072-666X2021-06-0112672510.3390/mi12060725Implantable Optrode Array for Optogenetic Modulation and Electrical Neural RecordingSaeyeong Jeon0Youjin Lee1Daeho Ryu2Yoon Kyung Cho3Yena Lee4Sang Beom Jun5Chang-Hyeon Ji6Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, KoreaDepartment of Electronic and Electrical Engineering, Ewha Womans University, Seoul 03760, KoreaDepartment of Electrical and Computer Engineering, Seoul National University, Seoul 08826, KoreaDepartment of Electronic and Electrical Engineering, Ewha Womans University, Seoul 03760, KoreaDepartment of Electronic and Electrical Engineering, Ewha Womans University, Seoul 03760, KoreaDepartment of Electronic and Electrical Engineering, Ewha Womans University, Seoul 03760, KoreaDepartment of Electronic and Electrical Engineering, Ewha Womans University, Seoul 03760, KoreaDuring the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices. Among them, the combination of optogenetics and electrophysiology provides an opportunity for facilitating optogenetic approaches. In this study, a novel design of an optrode array was proposed for realizing optical modulation and electrophysiological recording. A 4 × 4 optrode array and five-channel recording electrodes were assembled as a disposable part, while a reusable part comprised an LED (light-emitting diode) source and a power line. After the characterization of the intensity of the light delivered at the fiber tips, in vivo animal experiment was performed with transgenic mice expressing channelrhodopsin, showing the effectiveness of optical activation and neural recording.https://www.mdpi.com/2072-666X/12/6/725optogeneticsoptrodeelectrophysiologyelectrodechannelrhodopsin |
| spellingShingle | Saeyeong Jeon Youjin Lee Daeho Ryu Yoon Kyung Cho Yena Lee Sang Beom Jun Chang-Hyeon Ji Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording Micromachines optogenetics optrode electrophysiology electrode channelrhodopsin |
| title | Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording |
| title_full | Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording |
| title_fullStr | Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording |
| title_full_unstemmed | Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording |
| title_short | Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording |
| title_sort | implantable optrode array for optogenetic modulation and electrical neural recording |
| topic | optogenetics optrode electrophysiology electrode channelrhodopsin |
| url | https://www.mdpi.com/2072-666X/12/6/725 |
| work_keys_str_mv | AT saeyeongjeon implantableoptrodearrayforoptogeneticmodulationandelectricalneuralrecording AT youjinlee implantableoptrodearrayforoptogeneticmodulationandelectricalneuralrecording AT daehoryu implantableoptrodearrayforoptogeneticmodulationandelectricalneuralrecording AT yoonkyungcho implantableoptrodearrayforoptogeneticmodulationandelectricalneuralrecording AT yenalee implantableoptrodearrayforoptogeneticmodulationandelectricalneuralrecording AT sangbeomjun implantableoptrodearrayforoptogeneticmodulationandelectricalneuralrecording AT changhyeonji implantableoptrodearrayforoptogeneticmodulationandelectricalneuralrecording |