Blood glucose level affects prognosis of patients who received intravenous thrombolysis after acute ischemic stroke? A meta-analysis
Background and objectivesIntravenous recombinant tissue plasminogen activator (rtPA) thrombolysis is an effective treatment for acute ischemic stroke. Hyperglycemia is a major risk factor for the occurrence, development, and prognosis of ischemic stroke. This meta-analysis purposefully estimates the...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1120779/full |
| _version_ | 1797848037746278400 |
|---|---|
| author | Yue Wang Guannan Jiang Jie Zhang Jingfeng Wang Wanchun You Juehua Zhu |
| author_facet | Yue Wang Guannan Jiang Jie Zhang Jingfeng Wang Wanchun You Juehua Zhu |
| author_sort | Yue Wang |
| collection | DOAJ |
| description | Background and objectivesIntravenous recombinant tissue plasminogen activator (rtPA) thrombolysis is an effective treatment for acute ischemic stroke. Hyperglycemia is a major risk factor for the occurrence, development, and prognosis of ischemic stroke. This meta-analysis purposefully estimates the association between hyperglycemia and poor prognosis in acute ischemic stroke patients receiving intravenous rtPA thrombolytic therapy.Materials and methodsAccording to the predefined inclusion criteria, we searched PubMed, Web of Science, and Cochrane Library databases. The association of high blood glucose(>140mg/dl) with symptomatic intracranial hemorrhage (sICH), poor clinical outcome and mortality at 90 days post-rtPA thrombolysis was studied using both a common effects model and a random effects model. Odds ratios (ORs) were plotted on forest plots.ResultsOf a total cohort of 2565 patients who received intravenous thrombolytic therapy, 721 had higher blood glucose. High glucose level significantly increased the odds of sICH (OR 1.80; 95% confidence interval(95%CI): 1.30- 2.50) and poor clinical outcome at 90 days (OR 1.82; 95%CI: 1.52-2.19), and all-cause mortality at 90 days (OR 2.51; 95%CI:1.65-3.82).ConclusionsIn our meta-analysis, high blood glucose was significantly associated with sICH, poor clinical outcome and higher mortality at 90 days. |
| first_indexed | 2024-04-09T18:22:03Z |
| format | Article |
| id | doaj.art-5f79a113f00e451fb258ffc76491ed08 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T18:22:03Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-5f79a113f00e451fb258ffc76491ed082023-04-12T05:51:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11207791120779Blood glucose level affects prognosis of patients who received intravenous thrombolysis after acute ischemic stroke? A meta-analysisYue Wang0Guannan Jiang1Jie Zhang2Jingfeng Wang3Wanchun You4Juehua Zhu5Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology, The Second People’s Hospital of Kunshan, Suzhou, ChinaDepartment of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaBackground and objectivesIntravenous recombinant tissue plasminogen activator (rtPA) thrombolysis is an effective treatment for acute ischemic stroke. Hyperglycemia is a major risk factor for the occurrence, development, and prognosis of ischemic stroke. This meta-analysis purposefully estimates the association between hyperglycemia and poor prognosis in acute ischemic stroke patients receiving intravenous rtPA thrombolytic therapy.Materials and methodsAccording to the predefined inclusion criteria, we searched PubMed, Web of Science, and Cochrane Library databases. The association of high blood glucose(>140mg/dl) with symptomatic intracranial hemorrhage (sICH), poor clinical outcome and mortality at 90 days post-rtPA thrombolysis was studied using both a common effects model and a random effects model. Odds ratios (ORs) were plotted on forest plots.ResultsOf a total cohort of 2565 patients who received intravenous thrombolytic therapy, 721 had higher blood glucose. High glucose level significantly increased the odds of sICH (OR 1.80; 95% confidence interval(95%CI): 1.30- 2.50) and poor clinical outcome at 90 days (OR 1.82; 95%CI: 1.52-2.19), and all-cause mortality at 90 days (OR 2.51; 95%CI:1.65-3.82).ConclusionsIn our meta-analysis, high blood glucose was significantly associated with sICH, poor clinical outcome and higher mortality at 90 days.https://www.frontiersin.org/articles/10.3389/fendo.2023.1120779/fullblood glucoseacute ischemic strokeintravenous thrombolytic therapyfunctional outcomesymptomatic intracranial hemorrhage |
| spellingShingle | Yue Wang Guannan Jiang Jie Zhang Jingfeng Wang Wanchun You Juehua Zhu Blood glucose level affects prognosis of patients who received intravenous thrombolysis after acute ischemic stroke? A meta-analysis Frontiers in Endocrinology blood glucose acute ischemic stroke intravenous thrombolytic therapy functional outcome symptomatic intracranial hemorrhage |
| title | Blood glucose level affects prognosis of patients who received intravenous thrombolysis after acute ischemic stroke? A meta-analysis |
| title_full | Blood glucose level affects prognosis of patients who received intravenous thrombolysis after acute ischemic stroke? A meta-analysis |
| title_fullStr | Blood glucose level affects prognosis of patients who received intravenous thrombolysis after acute ischemic stroke? A meta-analysis |
| title_full_unstemmed | Blood glucose level affects prognosis of patients who received intravenous thrombolysis after acute ischemic stroke? A meta-analysis |
| title_short | Blood glucose level affects prognosis of patients who received intravenous thrombolysis after acute ischemic stroke? A meta-analysis |
| title_sort | blood glucose level affects prognosis of patients who received intravenous thrombolysis after acute ischemic stroke a meta analysis |
| topic | blood glucose acute ischemic stroke intravenous thrombolytic therapy functional outcome symptomatic intracranial hemorrhage |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1120779/full |
| work_keys_str_mv | AT yuewang bloodglucoselevelaffectsprognosisofpatientswhoreceivedintravenousthrombolysisafteracuteischemicstrokeametaanalysis AT guannanjiang bloodglucoselevelaffectsprognosisofpatientswhoreceivedintravenousthrombolysisafteracuteischemicstrokeametaanalysis AT jiezhang bloodglucoselevelaffectsprognosisofpatientswhoreceivedintravenousthrombolysisafteracuteischemicstrokeametaanalysis AT jingfengwang bloodglucoselevelaffectsprognosisofpatientswhoreceivedintravenousthrombolysisafteracuteischemicstrokeametaanalysis AT wanchunyou bloodglucoselevelaffectsprognosisofpatientswhoreceivedintravenousthrombolysisafteracuteischemicstrokeametaanalysis AT juehuazhu bloodglucoselevelaffectsprognosisofpatientswhoreceivedintravenousthrombolysisafteracuteischemicstrokeametaanalysis |