Gold Nanoparticle-Mediated Photoporation Enables Delivery of Macromolecules over a Wide Range of Molecular Weights in Human CD4+ T Cells

Gold Nanoparticle-Mediated Photoporation Enables Delivery of Macromolecules over a Wide Range of Molecular Weights in Human CD4+ T Cells

The modification of CD4+ T cells with exogenous nucleic acids or proteins is a critical step in several research and therapeutic applications, such as HIV studies and cancer immunotherapies. However, efficient cell transfections are not always easily achieved when working with these primary hard-to-...

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Bibliographic Details
Main Authors: Laurens Raes, Clarissa Van Hecke, Julie Michiels, Stephan Stremersch, Juan C. Fraire, Toon Brans, Ranhua Xiong, Stefaan De Smedt, Linos Vandekerckhove, Koen Raemdonck, Kevin Braeckmans
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Crystals
Subjects:
gold nanoparticles
vapor nanobubble
photoporation
T cells
intracellular delivery
macromolecules
Online Access:https://www.mdpi.com/2073-4352/9/8/411

Internet

https://www.mdpi.com/2073-4352/9/8/411

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