Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model
Summary: In Alzheimer’s disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought to be one of the key biological mechanisms of hyperexcitability. However, it is still unknown how INs ar...
Main Authors: | Takehiro Kudo, Hiroyuki Takuwa, Manami Takahashi, Takuya Urushihata, Masafumi Shimojo, Kazuaki Sampei, Mitsugu Yamanaka, Yutaka Tomita, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-04-01
|
Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223004194 |
Similar Items
-
Primary cilia are required for the persistence of memory and stabilization of perineuronal nets
by: Vladimir Jovasevic, et al.
Published: (2021-06-01) -
In Vivo Tau Imaging for a Diagnostic Platform of Tauopathy Using the rTg4510 Mouse Line
by: Naruhiko Sahara, et al.
Published: (2017-12-01) -
Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta
by: Sara Hijazi, et al.
Published: (2020-07-01) -
Altered low-frequency brain rhythms precede changes in gamma power during tauopathy
by: Fabio R. Rodrigues, et al.
Published: (2022-10-01) -
A comprehensive atlas of perineuronal net distribution and colocalization with parvalbumin in the adult mouse brain
by: Leonardo Lupori, et al.
Published: (2023-07-01)