Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media

Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media

Otitis media (OM) is a pervasive disease that involves hearing loss and severe complications. In our previous study, we successfully established a mouse model of human OM using Tlr2tm1Kir (TLR2–/–) mice with middle ear (ME) inoculation of streptococcal peptidoglycan-polysaccharide (PGPS). In this st...

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Bibliographic Details
Main Authors: Daoli Xie, Tong Zhao, Xiaolin Zhang, Lihong Kui, Qin Wang, Yuancheng Wu, Tihua Zheng, Peng Ma, Yan Zhang, Helen Molteni, Ruishuang Geng, Ying Yang, Bo Li, Qing Yin Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
otitis media
TLR2
autophagy
PGPS
rapamycin
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.753369/full

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