Non-Invasive Prenatal Testing: Current Perspectives and Future Challenges
Fetal aneuploidies are among the most common causes of miscarriages, perinatal mortality and neurodevelopmental impairment. During the last 70 years, many efforts have been made in order to improve prenatal diagnosis and prenatal screening of these conditions. Recently, the use of cell-free fetal DN...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/1/15 |
| _version_ | 1797543565696434176 |
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| author | Luigi Carbone Federica Cariati Laura Sarno Alessandro Conforti Francesca Bagnulo Ida Strina Lucio Pastore Giuseppe Maria Maruotti Carlo Alviggi |
| author_facet | Luigi Carbone Federica Cariati Laura Sarno Alessandro Conforti Francesca Bagnulo Ida Strina Lucio Pastore Giuseppe Maria Maruotti Carlo Alviggi |
| author_sort | Luigi Carbone |
| collection | DOAJ |
| description | Fetal aneuploidies are among the most common causes of miscarriages, perinatal mortality and neurodevelopmental impairment. During the last 70 years, many efforts have been made in order to improve prenatal diagnosis and prenatal screening of these conditions. Recently, the use of cell-free fetal DNA (cff-DNA) testing has been increasingly used in different countries, representing an opportunity for non-invasive prenatal screening of pregnant women. The aim of this narrative review is to describe the state of the art and the main strengths and limitations of this test for prenatal screening of fetal aneuploidies. |
| first_indexed | 2024-03-10T13:47:25Z |
| format | Article |
| id | doaj.art-5f7dc298a8784062b0d70d643c7df4e6 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T13:47:25Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-5f7dc298a8784062b0d70d643c7df4e62023-11-21T02:29:03ZengMDPI AGGenes2073-44252020-12-011211510.3390/genes12010015Non-Invasive Prenatal Testing: Current Perspectives and Future ChallengesLuigi Carbone0Federica Cariati1Laura Sarno2Alessandro Conforti3Francesca Bagnulo4Ida Strina5Lucio Pastore6Giuseppe Maria Maruotti7Carlo Alviggi8Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, Università di Napoli Federico II, 80131 Naples, ItalyCEINGE-Biotecnologie Avanzate s.c.a.r.l., 80145 Naples, ItalyDipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, Università di Napoli Federico II, 80131 Naples, ItalyDipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, Università di Napoli Federico II, 80131 Naples, ItalyFertility Unit, Maternal-Child Department, AOU Policlinico Federico II, 80131 Naples, ItalyDipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, Università di Napoli Federico II, 80131 Naples, ItalyCEINGE-Biotecnologie Avanzate s.c.a.r.l., 80145 Naples, ItalyDipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, Università di Napoli Federico II, 80131 Naples, ItalyDipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, Università di Napoli Federico II, 80131 Naples, ItalyFetal aneuploidies are among the most common causes of miscarriages, perinatal mortality and neurodevelopmental impairment. During the last 70 years, many efforts have been made in order to improve prenatal diagnosis and prenatal screening of these conditions. Recently, the use of cell-free fetal DNA (cff-DNA) testing has been increasingly used in different countries, representing an opportunity for non-invasive prenatal screening of pregnant women. The aim of this narrative review is to describe the state of the art and the main strengths and limitations of this test for prenatal screening of fetal aneuploidies.https://www.mdpi.com/2073-4425/12/1/15non-invasive prenatal testingprenatal screeningfetal aneuploidiescell-free fetal DNAfetal fraction |
| spellingShingle | Luigi Carbone Federica Cariati Laura Sarno Alessandro Conforti Francesca Bagnulo Ida Strina Lucio Pastore Giuseppe Maria Maruotti Carlo Alviggi Non-Invasive Prenatal Testing: Current Perspectives and Future Challenges Genes non-invasive prenatal testing prenatal screening fetal aneuploidies cell-free fetal DNA fetal fraction |
| title | Non-Invasive Prenatal Testing: Current Perspectives and Future Challenges |
| title_full | Non-Invasive Prenatal Testing: Current Perspectives and Future Challenges |
| title_fullStr | Non-Invasive Prenatal Testing: Current Perspectives and Future Challenges |
| title_full_unstemmed | Non-Invasive Prenatal Testing: Current Perspectives and Future Challenges |
| title_short | Non-Invasive Prenatal Testing: Current Perspectives and Future Challenges |
| title_sort | non invasive prenatal testing current perspectives and future challenges |
| topic | non-invasive prenatal testing prenatal screening fetal aneuploidies cell-free fetal DNA fetal fraction |
| url | https://www.mdpi.com/2073-4425/12/1/15 |
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