Lamellar keratoplasty using decellularised porcine cornea as an acellular scaffold graft for surgical management of deep corneal ulcer in a dog
Corneal ulcers are one of the most common eye affection in domestic animals, especially dogs. In preclinical studies, porcine corneas were used regularly as an animal model due to its relative similarity to human cornea and its availability in great numbers from slaughter houses. In the present s...
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Director of Academics and Research, Kerala Veterinary and Animal Sciences University
2023-06-01
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| Series: | Journal of Veterinary and Animal Sciences |
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| Online Access: | https://jvas.in/public_html/upload/article_file/article_file_ry2zhc.pdf?t=ry2zhc |
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| author | A. Aswathy Mohan S. Anoop K. D. John Martin Laiju M. Philip V. N. Vasudevan Ashlin Michael |
| author_facet | A. Aswathy Mohan S. Anoop K. D. John Martin Laiju M. Philip V. N. Vasudevan Ashlin Michael |
| author_sort | A. Aswathy Mohan |
| collection | DOAJ |
| description | Corneal ulcers are one of the most common eye affection in domestic animals, especially
dogs. In preclinical studies, porcine corneas were used regularly as an animal model due to its
relative similarity to human cornea and its availability in great numbers from slaughter houses. In the
present study, decellularised porcine cornea was used for corneal grafting as an acellular scaffold
graft material in a case presented with deep corneal ulcer. The efficiency of the graft material was
analysed on the day of presentation, days 7, 14, 21 and 60 post grafting, based on corneal clarity,
oedema, neovascularisation, pigmentation, visual function and scar tissue formation. Decellularised
porcine corneas were found to be very convenient to handle during surgery, provided good tectonic
support, had good tissue biocompatibility and produced only mild to moderate graft opacity. |
| first_indexed | 2024-03-12T22:25:39Z |
| format | Article |
| id | doaj.art-5f7e2bdd9e694bf98ac07a16826db1c0 |
| institution | Directory Open Access Journal |
| issn | 0971-0701 2582-0605 |
| language | English |
| last_indexed | 2024-03-12T22:25:39Z |
| publishDate | 2023-06-01 |
| publisher | Director of Academics and Research, Kerala Veterinary and Animal Sciences University |
| record_format | Article |
| series | Journal of Veterinary and Animal Sciences |
| spelling | doaj.art-5f7e2bdd9e694bf98ac07a16826db1c02023-07-22T05:09:57ZengDirector of Academics and Research, Kerala Veterinary and Animal Sciences UniversityJournal of Veterinary and Animal Sciences0971-07012582-06052023-06-0154260060310.51966/jvas.2023.54.2.600-603Lamellar keratoplasty using decellularised porcine cornea as an acellular scaffold graft for surgical management of deep corneal ulcer in a dogA. Aswathy Mohan0S. Anoop1https://orcid.org/0000-0002-0054-6164K. D. John Martin2Laiju M. Philip3https://orcid.org/0000-0003-2265-5924V. N. Vasudevan4https://orcid.org/0000-0002-2788-3590Ashlin Michael5MVSc Scholar, Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, IndiaProfessor and Head, Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Kerala, IndiaProfessor and Head, Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, IndiaAssistant Professor, Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, IndiaAssociate Professor and Head, Department of Livestock Products Technology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, IndiaMVSc Scholar, Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Kerala Veterinary and Animal Sciences University, Kerala, IndiaCorneal ulcers are one of the most common eye affection in domestic animals, especially dogs. In preclinical studies, porcine corneas were used regularly as an animal model due to its relative similarity to human cornea and its availability in great numbers from slaughter houses. In the present study, decellularised porcine cornea was used for corneal grafting as an acellular scaffold graft material in a case presented with deep corneal ulcer. The efficiency of the graft material was analysed on the day of presentation, days 7, 14, 21 and 60 post grafting, based on corneal clarity, oedema, neovascularisation, pigmentation, visual function and scar tissue formation. Decellularised porcine corneas were found to be very convenient to handle during surgery, provided good tectonic support, had good tissue biocompatibility and produced only mild to moderate graft opacity.https://jvas.in/public_html/upload/article_file/article_file_ry2zhc.pdf?t=ry2zhcdecellularised porcine corneadeep corneal ulcersgrafting |
| spellingShingle | A. Aswathy Mohan S. Anoop K. D. John Martin Laiju M. Philip V. N. Vasudevan Ashlin Michael Lamellar keratoplasty using decellularised porcine cornea as an acellular scaffold graft for surgical management of deep corneal ulcer in a dog Journal of Veterinary and Animal Sciences decellularised porcine cornea deep corneal ulcers grafting |
| title | Lamellar keratoplasty using decellularised porcine cornea as an acellular scaffold graft for surgical management of deep corneal ulcer in a dog |
| title_full | Lamellar keratoplasty using decellularised porcine cornea as an acellular scaffold graft for surgical management of deep corneal ulcer in a dog |
| title_fullStr | Lamellar keratoplasty using decellularised porcine cornea as an acellular scaffold graft for surgical management of deep corneal ulcer in a dog |
| title_full_unstemmed | Lamellar keratoplasty using decellularised porcine cornea as an acellular scaffold graft for surgical management of deep corneal ulcer in a dog |
| title_short | Lamellar keratoplasty using decellularised porcine cornea as an acellular scaffold graft for surgical management of deep corneal ulcer in a dog |
| title_sort | lamellar keratoplasty using decellularised porcine cornea as an acellular scaffold graft for surgical management of deep corneal ulcer in a dog |
| topic | decellularised porcine cornea deep corneal ulcers grafting |
| url | https://jvas.in/public_html/upload/article_file/article_file_ry2zhc.pdf?t=ry2zhc |
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