The Correlation of Ten Immune Checkpoint Gene Expressions and Their Association with Gastric Cancer Development
In the immunotherapy based on immune checkpoint inhibition (IC), additional ICs are being studied to increase its effectiveness. An almost unstudied feature is the possible co-expression of ICs, which can determine the therapeutic efficacy of their inhibition. For the selection of promising ICs, inf...
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/13846 |
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| author | Danzan Mansorunov Natalya Apanovich Fatimat Kipkeeva Maxim Nikulin Olga Malikhova Ivan Stilidi Alexander Karpukhin |
| author_facet | Danzan Mansorunov Natalya Apanovich Fatimat Kipkeeva Maxim Nikulin Olga Malikhova Ivan Stilidi Alexander Karpukhin |
| author_sort | Danzan Mansorunov |
| collection | DOAJ |
| description | In the immunotherapy based on immune checkpoint inhibition (IC), additional ICs are being studied to increase its effectiveness. An almost unstudied feature is the possible co-expression of ICs, which can determine the therapeutic efficacy of their inhibition. For the selection of promising ICs, information on the association of their expression with cancer development may be essential. We have obtained data on the expression correlation of <i>ADAM17</i>, <i>PVR</i>, <i>TDO2</i>, <i>CD274</i>, <i>CD276</i>, <i>CEACAM1</i>, <i>IDO1</i>, <i>LGALS3</i>, <i>LGALS9</i>, and <i>HHLA2</i> genes in gastric cancer (GC). All but one, <i>TDO2</i>, have other IC genes with co-expression at some stage. At the metastatic stage, the expression of the <i>IDO1</i> does not correlate with any other gene. The correlations are positive, but the expressions of the <i>CD276</i> and <i>CEACAM1</i> genes are negatively correlated. The expression of <i>TDO2</i> and <i>LGALS3</i> is associated with GC metastasis. The expression of <i>TDO2</i> four-fold higher in metastatic tumors than in non-metastatic tumors, but <i>LGALS3</i> was two-fold lower. The differentiation is associated with <i>IDO1</i>. The revealed features of <i>TDO2</i>, with a significant increase in expression at the metastatic stage and the absence of other IC genes with correlated expression indicates that the prospect of inhibiting <i>TDO2</i> in metastatic GC. IDO1 may be considered for inhibition in low-differentiated tumors. |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:17:39Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5f7e93b490c34cff82c5f935bf8e8f062023-11-24T08:34:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221384610.3390/ijms232213846The Correlation of Ten Immune Checkpoint Gene Expressions and Their Association with Gastric Cancer DevelopmentDanzan Mansorunov0Natalya Apanovich1Fatimat Kipkeeva2Maxim Nikulin3Olga Malikhova4Ivan Stilidi5Alexander Karpukhin6Research Centre for Medical Genetics, 1 Moskvorechye St., 115522 Moscow, RussiaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115522 Moscow, RussiaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115522 Moscow, RussiaBlokhin National Medical Research Center of Oncology of the Ministry of Health of Russia, 24 Kashirskoe Shosse, 115478 Moscow, RussiaBlokhin National Medical Research Center of Oncology of the Ministry of Health of Russia, 24 Kashirskoe Shosse, 115478 Moscow, RussiaBlokhin National Medical Research Center of Oncology of the Ministry of Health of Russia, 24 Kashirskoe Shosse, 115478 Moscow, RussiaResearch Centre for Medical Genetics, 1 Moskvorechye St., 115522 Moscow, RussiaIn the immunotherapy based on immune checkpoint inhibition (IC), additional ICs are being studied to increase its effectiveness. An almost unstudied feature is the possible co-expression of ICs, which can determine the therapeutic efficacy of their inhibition. For the selection of promising ICs, information on the association of their expression with cancer development may be essential. We have obtained data on the expression correlation of <i>ADAM17</i>, <i>PVR</i>, <i>TDO2</i>, <i>CD274</i>, <i>CD276</i>, <i>CEACAM1</i>, <i>IDO1</i>, <i>LGALS3</i>, <i>LGALS9</i>, and <i>HHLA2</i> genes in gastric cancer (GC). All but one, <i>TDO2</i>, have other IC genes with co-expression at some stage. At the metastatic stage, the expression of the <i>IDO1</i> does not correlate with any other gene. The correlations are positive, but the expressions of the <i>CD276</i> and <i>CEACAM1</i> genes are negatively correlated. The expression of <i>TDO2</i> and <i>LGALS3</i> is associated with GC metastasis. The expression of <i>TDO2</i> four-fold higher in metastatic tumors than in non-metastatic tumors, but <i>LGALS3</i> was two-fold lower. The differentiation is associated with <i>IDO1</i>. The revealed features of <i>TDO2</i>, with a significant increase in expression at the metastatic stage and the absence of other IC genes with correlated expression indicates that the prospect of inhibiting <i>TDO2</i> in metastatic GC. IDO1 may be considered for inhibition in low-differentiated tumors.https://www.mdpi.com/1422-0067/23/22/13846immune checkpointsexpressioncorrelationgastric cancer |
| spellingShingle | Danzan Mansorunov Natalya Apanovich Fatimat Kipkeeva Maxim Nikulin Olga Malikhova Ivan Stilidi Alexander Karpukhin The Correlation of Ten Immune Checkpoint Gene Expressions and Their Association with Gastric Cancer Development International Journal of Molecular Sciences immune checkpoints expression correlation gastric cancer |
| title | The Correlation of Ten Immune Checkpoint Gene Expressions and Their Association with Gastric Cancer Development |
| title_full | The Correlation of Ten Immune Checkpoint Gene Expressions and Their Association with Gastric Cancer Development |
| title_fullStr | The Correlation of Ten Immune Checkpoint Gene Expressions and Their Association with Gastric Cancer Development |
| title_full_unstemmed | The Correlation of Ten Immune Checkpoint Gene Expressions and Their Association with Gastric Cancer Development |
| title_short | The Correlation of Ten Immune Checkpoint Gene Expressions and Their Association with Gastric Cancer Development |
| title_sort | correlation of ten immune checkpoint gene expressions and their association with gastric cancer development |
| topic | immune checkpoints expression correlation gastric cancer |
| url | https://www.mdpi.com/1422-0067/23/22/13846 |
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