Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats

Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats

Abstract Background 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) is a widely used entactogenic drug known to impair cognitive functions on the long-run. Both hippocampal and frontal cortical regions have well established roles in behavior, memory formation and other cognitive tasks and damage...

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Bibliographic Details
Main Authors: Peter Petschner, Viola Tamasi, Csaba Adori, Eszter Kirilly, Romeo D. Ando, Laszlo Tothfalusi, Gyorgy Bagdy
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Genomics
Subjects:
Ecstasy
Endocannabinoid
CB1
RhoGTPase
Serotonin
Gene expression
Online Access:http://link.springer.com/article/10.1186/s12864-018-4929-x

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