Genome-wide bioinformatics analysis of human protease capacity for proteolytic cleavage of the SARS-CoV-2 spike glycoprotein

Genome-wide bioinformatics analysis of human protease capacity for proteolytic cleavage of the SARS-CoV-2 spike glycoprotein

ABSTRACTSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) primarily enters the cell by binding the virus’s spike (S) glycoprotein to the angiotensin-converting enzyme 2 receptor on the cell surface, followed by proteolytic cleavage by host proteases. Studies have identified furin and tran...

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Bibliographic Details
Main Authors: Evgenii V. Matveev, Gennady V. Ponomarev, Marat D. Kazanov
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
spike glycoprotein
proteolytic activation
protease
proteolysis
furin
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03530-23

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