Association between body mass index, metabolic syndrome and common urologic conditions: a cross-sectional study using a large multi-institutional database from the United States
AbstractIntroduction The study aims to determine whether body mass index (BMI), metabolic syndrome (MS) or its individual components (primary hypertension, type 2 diabetes mellitus and dyslipidemias) are risk factors for common urological diseases.Materials and methods Cross-sectional study with dat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2197293 |
| _version_ | 1797353734207963136 |
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| author | Maria Camila Suarez Arbelaez Sirpi Nackeeran Khushi Shah Ruben Blachman-Braun Isaac Bronson Maxwell Towe Abhishek Bhat Robert Marcovich Ranjith Ramasamy Hemendra N. Shah |
| author_facet | Maria Camila Suarez Arbelaez Sirpi Nackeeran Khushi Shah Ruben Blachman-Braun Isaac Bronson Maxwell Towe Abhishek Bhat Robert Marcovich Ranjith Ramasamy Hemendra N. Shah |
| author_sort | Maria Camila Suarez Arbelaez |
| collection | DOAJ |
| description | AbstractIntroduction The study aims to determine whether body mass index (BMI), metabolic syndrome (MS) or its individual components (primary hypertension, type 2 diabetes mellitus and dyslipidemias) are risk factors for common urological diseases.Materials and methods Cross-sectional study with data collected on February 28, 2022 from the TriNetX Research Network. Patients were divided in cohorts according to their BMI, presence of MS (BMI > 30 kg/m2, type 2 diabetes mellitus, primary hypertension and disorders of lipoprotein metabolism) and its individual components and its association with common urological conditions was determined. For each analysis, odds ratio (OR) with 95% confidence intervals were calculated. Statistical significance was assessed at p < .05.Results BMI > 30 kg/m2 was associated with increased risk of lithiasis, kidney cancer, overactive bladder, male hypogonadism, benign prostatic hyperplasia, and erectile dysfunction (p < .05). On the contrary, BMI was inversely associated with ureteral, bladder and prostate cancer (p < .05). In all urological diseases, MS was the strongest risk factor, with prostate cancer (OR = 2.53) showing the weakest and male hypogonadism the strongest (OR = 13.00) associations.Conclusions MS and its individual components were significant risk factors for common urological conditions. Hence holistic approaches with lifestyle modification might prevent common urological disease.Key messagesOverall, metabolic syndrome is the strongest risk factor for all the analysed urological diseases.Abnormally high body mass index can be a risk or protective factor depending on the threshold and urological disease that are being evaluated.Metabolic syndrome and increased BMI should be considered important factors associated to the prevalence of common urological diseases. |
| first_indexed | 2024-03-08T13:35:20Z |
| format | Article |
| id | doaj.art-5f7fd0169ac1419b9acc43abada8f3dd |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:35:20Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-5f7fd0169ac1419b9acc43abada8f3dd2024-01-16T19:13:20ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155110.1080/07853890.2023.2197293Association between body mass index, metabolic syndrome and common urologic conditions: a cross-sectional study using a large multi-institutional database from the United StatesMaria Camila Suarez Arbelaez0Sirpi Nackeeran1Khushi Shah2Ruben Blachman-Braun3Isaac Bronson4Maxwell Towe5Abhishek Bhat6Robert Marcovich7Ranjith Ramasamy8Hemendra N. Shah9Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USADesai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USADesai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USADesai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USAUMass Chann Medical School, University of Massachusetts, Amherst, MA, USADesai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USADesai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USADesai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USADesai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USADesai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USAAbstractIntroduction The study aims to determine whether body mass index (BMI), metabolic syndrome (MS) or its individual components (primary hypertension, type 2 diabetes mellitus and dyslipidemias) are risk factors for common urological diseases.Materials and methods Cross-sectional study with data collected on February 28, 2022 from the TriNetX Research Network. Patients were divided in cohorts according to their BMI, presence of MS (BMI > 30 kg/m2, type 2 diabetes mellitus, primary hypertension and disorders of lipoprotein metabolism) and its individual components and its association with common urological conditions was determined. For each analysis, odds ratio (OR) with 95% confidence intervals were calculated. Statistical significance was assessed at p < .05.Results BMI > 30 kg/m2 was associated with increased risk of lithiasis, kidney cancer, overactive bladder, male hypogonadism, benign prostatic hyperplasia, and erectile dysfunction (p < .05). On the contrary, BMI was inversely associated with ureteral, bladder and prostate cancer (p < .05). In all urological diseases, MS was the strongest risk factor, with prostate cancer (OR = 2.53) showing the weakest and male hypogonadism the strongest (OR = 13.00) associations.Conclusions MS and its individual components were significant risk factors for common urological conditions. Hence holistic approaches with lifestyle modification might prevent common urological disease.Key messagesOverall, metabolic syndrome is the strongest risk factor for all the analysed urological diseases.Abnormally high body mass index can be a risk or protective factor depending on the threshold and urological disease that are being evaluated.Metabolic syndrome and increased BMI should be considered important factors associated to the prevalence of common urological diseases.https://www.tandfonline.com/doi/10.1080/07853890.2023.2197293BMI; diabetes mellituserectile dysfunctionlithiasismetabolic syndromeobesityoveractive bladder |
| spellingShingle | Maria Camila Suarez Arbelaez Sirpi Nackeeran Khushi Shah Ruben Blachman-Braun Isaac Bronson Maxwell Towe Abhishek Bhat Robert Marcovich Ranjith Ramasamy Hemendra N. Shah Association between body mass index, metabolic syndrome and common urologic conditions: a cross-sectional study using a large multi-institutional database from the United States Annals of Medicine BMI; diabetes mellitus erectile dysfunction lithiasis metabolic syndrome obesity overactive bladder |
| title | Association between body mass index, metabolic syndrome and common urologic conditions: a cross-sectional study using a large multi-institutional database from the United States |
| title_full | Association between body mass index, metabolic syndrome and common urologic conditions: a cross-sectional study using a large multi-institutional database from the United States |
| title_fullStr | Association between body mass index, metabolic syndrome and common urologic conditions: a cross-sectional study using a large multi-institutional database from the United States |
| title_full_unstemmed | Association between body mass index, metabolic syndrome and common urologic conditions: a cross-sectional study using a large multi-institutional database from the United States |
| title_short | Association between body mass index, metabolic syndrome and common urologic conditions: a cross-sectional study using a large multi-institutional database from the United States |
| title_sort | association between body mass index metabolic syndrome and common urologic conditions a cross sectional study using a large multi institutional database from the united states |
| topic | BMI; diabetes mellitus erectile dysfunction lithiasis metabolic syndrome obesity overactive bladder |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2197293 |
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