The analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic review
Background: Duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI) with clinical efficacy in chronic pain conditions. In this study, we aim to evaluate the analgesic effect and safety of duloxetine in total knee arthroplasty (TKA). Methods: A systematic search was completed on MEDLIN...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-05-01
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| Series: | Journal of Orthopaedic Surgery |
| Online Access: | https://doi.org/10.1177/10225536231177482 |
| _version_ | 1797809713407066112 |
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| author | Emad Kouhestani Reza Minaei Amir Salimi Yoosef Mehrabi Shakila Meshkat |
| author_facet | Emad Kouhestani Reza Minaei Amir Salimi Yoosef Mehrabi Shakila Meshkat |
| author_sort | Emad Kouhestani |
| collection | DOAJ |
| description | Background: Duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI) with clinical efficacy in chronic pain conditions. In this study, we aim to evaluate the analgesic effect and safety of duloxetine in total knee arthroplasty (TKA). Methods: A systematic search was completed on MEDLINE, PsycINFO, and Embase from inception to December 2022 to find relevant articles. We used Cochrane methodology to evaluate the bias of included studies. Investigated outcomes included postoperative pain, opioid consumption, adverse events (AEs), range of motion (ROM), emotional and physical function, patient satisfaction, patient-controlled analgesia (PCA), knee-specific outcomes, wound complications, skin temperature, inflammatory markers, length of stay, and incidence of manipulations. Results: Nine articles involving 942 participants were included in our systematic review. Out of nine papers, eight were randomized clinical trials and one was a retrospective study. The results of these studies indicated the analgesic effect of duloxetine on postoperative pain, which was measured using numeric rating scale and visual analogue scale. Deluxetine was also effective in reducing the morphine requirement and wound complications and enhancing patient satisfaction after surgery. However, the results on ROM, PCA, and knee-specific outcomes were contraventional. Deluxetine was generally safe without serious AEs. The most common AEs included headache, nausea, vomiting, dry mouth, and constipation. Conclusion: Duloxetine may be an effective treatment option for postoperative pain following TKA, but further rigorously designed and well-controlled randomized trials are required. |
| first_indexed | 2024-03-13T06:56:52Z |
| format | Article |
| id | doaj.art-5f821aaa6e9a4808b83b8ef486f71ba0 |
| institution | Directory Open Access Journal |
| issn | 2309-4990 |
| language | English |
| last_indexed | 2024-03-13T06:56:52Z |
| publishDate | 2023-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Orthopaedic Surgery |
| spelling | doaj.art-5f821aaa6e9a4808b83b8ef486f71ba02023-06-07T05:33:32ZengSAGE PublishingJournal of Orthopaedic Surgery2309-49902023-05-013110.1177/10225536231177482The analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic reviewEmad KouhestaniReza MinaeiAmir SalimiYoosef MehrabiShakila MeshkatBackground: Duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI) with clinical efficacy in chronic pain conditions. In this study, we aim to evaluate the analgesic effect and safety of duloxetine in total knee arthroplasty (TKA). Methods: A systematic search was completed on MEDLINE, PsycINFO, and Embase from inception to December 2022 to find relevant articles. We used Cochrane methodology to evaluate the bias of included studies. Investigated outcomes included postoperative pain, opioid consumption, adverse events (AEs), range of motion (ROM), emotional and physical function, patient satisfaction, patient-controlled analgesia (PCA), knee-specific outcomes, wound complications, skin temperature, inflammatory markers, length of stay, and incidence of manipulations. Results: Nine articles involving 942 participants were included in our systematic review. Out of nine papers, eight were randomized clinical trials and one was a retrospective study. The results of these studies indicated the analgesic effect of duloxetine on postoperative pain, which was measured using numeric rating scale and visual analogue scale. Deluxetine was also effective in reducing the morphine requirement and wound complications and enhancing patient satisfaction after surgery. However, the results on ROM, PCA, and knee-specific outcomes were contraventional. Deluxetine was generally safe without serious AEs. The most common AEs included headache, nausea, vomiting, dry mouth, and constipation. Conclusion: Duloxetine may be an effective treatment option for postoperative pain following TKA, but further rigorously designed and well-controlled randomized trials are required.https://doi.org/10.1177/10225536231177482 |
| spellingShingle | Emad Kouhestani Reza Minaei Amir Salimi Yoosef Mehrabi Shakila Meshkat The analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic review Journal of Orthopaedic Surgery |
| title | The analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic review |
| title_full | The analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic review |
| title_fullStr | The analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic review |
| title_full_unstemmed | The analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic review |
| title_short | The analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic review |
| title_sort | analgesic effect and safety of duloxetine in total knee arthroplasty a systematic review |
| url | https://doi.org/10.1177/10225536231177482 |
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