Surgical Management of Adrenocortical Carcinoma: Current Highlights
Introduction: Adrenocortical carcinoma (ACC) is a rare tumor, often discovered at an advanced stage and associated with poor prognosis. Treatment is guided by staging according to the European Network for the Study of Adrenal Tumors (ENSAT) classification. Surgery is the treatment of choice for ACC....
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/8/909 |
| _version_ | 1797524576207372288 |
|---|---|
| author | Giuseppe Cavallaro Mariarita Tarallo Ambra Chiappini Daniele Crocetti Andrea Polistena Luigi Petramala Simone Sibio Giorgio De Toma Enrico Fiori Claudio Letizia |
| author_facet | Giuseppe Cavallaro Mariarita Tarallo Ambra Chiappini Daniele Crocetti Andrea Polistena Luigi Petramala Simone Sibio Giorgio De Toma Enrico Fiori Claudio Letizia |
| author_sort | Giuseppe Cavallaro |
| collection | DOAJ |
| description | Introduction: Adrenocortical carcinoma (ACC) is a rare tumor, often discovered at an advanced stage and associated with poor prognosis. Treatment is guided by staging according to the European Network for the Study of Adrenal Tumors (ENSAT) classification. Surgery is the treatment of choice for ACC. The aim of this review is to provide a complete overview on surgical approaches and management of adrenocortical carcinoma. Methods: This comprehensive review has been carried out according to the PRISMA statement. The literature sources were the databases PubMed, Scopus and Cochrane Library. The search thread was: ((surgery) OR (adrenalectomy)) AND (adrenocortical carcinoma). Results: Among all studies identified, 17 were selected for the review. All of them were retrospective. A total of 2498 patients were included in the studies, of whom 734 were treated by mini-invasive approaches and 1764 patients were treated by open surgery. Conclusions: Surgery is the treatment of choice for ACC. Open adrenalectomy (OA) is defined as the gold standard. In recent years laparoscopic adrenalectomy (LA) has gained more popularity. No significant differences were reported for overall recurrence rate, time to recurrence, and cancer-specific mortality between LA and OA, in particular for Stage I-II. Robotic adrenalectomy (RA) has several advantages compared to LA, but there is still a lack of specific documentation on RA use in ACC. |
| first_indexed | 2024-03-10T08:59:24Z |
| format | Article |
| id | doaj.art-5f821d1957cd48f2a40b10ec633ab4e2 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T08:59:24Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-5f821d1957cd48f2a40b10ec633ab4e22023-11-22T06:51:49ZengMDPI AGBiomedicines2227-90592021-07-019890910.3390/biomedicines9080909Surgical Management of Adrenocortical Carcinoma: Current HighlightsGiuseppe Cavallaro0Mariarita Tarallo1Ambra Chiappini2Daniele Crocetti3Andrea Polistena4Luigi Petramala5Simone Sibio6Giorgio De Toma7Enrico Fiori8Claudio Letizia9Department of Surgery “Pietro Valdoni”, Sapienza University, 00161 Rome, ItalyDepartment of Surgery “Pietro Valdoni”, Sapienza University, 00161 Rome, ItalyDepartment of Surgery “Pietro Valdoni”, Sapienza University, 00161 Rome, ItalyDepartment of Surgery “Pietro Valdoni”, Sapienza University, 00161 Rome, ItalyDepartment of Surgery “Pietro Valdoni”, Sapienza University, 00161 Rome, ItalyDepartment of Translational and Precision Medicine, Sapienza University, 00161 Rome, ItalyDepartment of Surgery “Pietro Valdoni”, Sapienza University, 00161 Rome, ItalyDepartment of Surgery “Pietro Valdoni”, Sapienza University, 00161 Rome, ItalyDepartment of Surgery “Pietro Valdoni”, Sapienza University, 00161 Rome, ItalyDepartment of Translational and Precision Medicine, Sapienza University, 00161 Rome, ItalyIntroduction: Adrenocortical carcinoma (ACC) is a rare tumor, often discovered at an advanced stage and associated with poor prognosis. Treatment is guided by staging according to the European Network for the Study of Adrenal Tumors (ENSAT) classification. Surgery is the treatment of choice for ACC. The aim of this review is to provide a complete overview on surgical approaches and management of adrenocortical carcinoma. Methods: This comprehensive review has been carried out according to the PRISMA statement. The literature sources were the databases PubMed, Scopus and Cochrane Library. The search thread was: ((surgery) OR (adrenalectomy)) AND (adrenocortical carcinoma). Results: Among all studies identified, 17 were selected for the review. All of them were retrospective. A total of 2498 patients were included in the studies, of whom 734 were treated by mini-invasive approaches and 1764 patients were treated by open surgery. Conclusions: Surgery is the treatment of choice for ACC. Open adrenalectomy (OA) is defined as the gold standard. In recent years laparoscopic adrenalectomy (LA) has gained more popularity. No significant differences were reported for overall recurrence rate, time to recurrence, and cancer-specific mortality between LA and OA, in particular for Stage I-II. Robotic adrenalectomy (RA) has several advantages compared to LA, but there is still a lack of specific documentation on RA use in ACC.https://www.mdpi.com/2227-9059/9/8/909adrenocortical carcinomacurrent methods of treatmentlaparoscopic adrenalectomyrobotic adrenalectomy |
| spellingShingle | Giuseppe Cavallaro Mariarita Tarallo Ambra Chiappini Daniele Crocetti Andrea Polistena Luigi Petramala Simone Sibio Giorgio De Toma Enrico Fiori Claudio Letizia Surgical Management of Adrenocortical Carcinoma: Current Highlights Biomedicines adrenocortical carcinoma current methods of treatment laparoscopic adrenalectomy robotic adrenalectomy |
| title | Surgical Management of Adrenocortical Carcinoma: Current Highlights |
| title_full | Surgical Management of Adrenocortical Carcinoma: Current Highlights |
| title_fullStr | Surgical Management of Adrenocortical Carcinoma: Current Highlights |
| title_full_unstemmed | Surgical Management of Adrenocortical Carcinoma: Current Highlights |
| title_short | Surgical Management of Adrenocortical Carcinoma: Current Highlights |
| title_sort | surgical management of adrenocortical carcinoma current highlights |
| topic | adrenocortical carcinoma current methods of treatment laparoscopic adrenalectomy robotic adrenalectomy |
| url | https://www.mdpi.com/2227-9059/9/8/909 |
| work_keys_str_mv | AT giuseppecavallaro surgicalmanagementofadrenocorticalcarcinomacurrenthighlights AT mariaritatarallo surgicalmanagementofadrenocorticalcarcinomacurrenthighlights AT ambrachiappini surgicalmanagementofadrenocorticalcarcinomacurrenthighlights AT danielecrocetti surgicalmanagementofadrenocorticalcarcinomacurrenthighlights AT andreapolistena surgicalmanagementofadrenocorticalcarcinomacurrenthighlights AT luigipetramala surgicalmanagementofadrenocorticalcarcinomacurrenthighlights AT simonesibio surgicalmanagementofadrenocorticalcarcinomacurrenthighlights AT giorgiodetoma surgicalmanagementofadrenocorticalcarcinomacurrenthighlights AT enricofiori surgicalmanagementofadrenocorticalcarcinomacurrenthighlights AT claudioletizia surgicalmanagementofadrenocorticalcarcinomacurrenthighlights |