Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy
Raman spectroscopy is a label-free method of obtaining detailed chemical information about samples. Its compatibility with living tissue makes it an attractive choice for biomedical analysis, yet its translation from a research tool to a clinical tool has been slow, hampered by fundamental Raman sca...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-07-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/17/7/1592 |
| _version_ | 1828394278932447232 |
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| author | Nandan K. Das Yichuan Dai Peng Liu Chuanzhen Hu Lieshu Tong Xiaoya Chen Zachary J. Smith |
| author_facet | Nandan K. Das Yichuan Dai Peng Liu Chuanzhen Hu Lieshu Tong Xiaoya Chen Zachary J. Smith |
| author_sort | Nandan K. Das |
| collection | DOAJ |
| description | Raman spectroscopy is a label-free method of obtaining detailed chemical information about samples. Its compatibility with living tissue makes it an attractive choice for biomedical analysis, yet its translation from a research tool to a clinical tool has been slow, hampered by fundamental Raman scattering issues such as long integration times and limited penetration depth. In this review we detail the how combining Raman spectroscopy with other techniques yields multimodal instruments that can help to surmount the translational barriers faced by Raman alone. We review Raman combined with several optical and non-optical methods, including fluorescence, elastic scattering, OCT, phase imaging, and mass spectrometry. In each section we highlight the power of each combination along with a brief history and presentation of representative results. Finally, we conclude with a perspective detailing both benefits and challenges for multimodal Raman measurements, and give thoughts on future directions in the field. |
| first_indexed | 2024-12-10T07:52:31Z |
| format | Article |
| id | doaj.art-5f82e045306644d0a49b60bdd62a8785 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-12-10T07:52:31Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-5f82e045306644d0a49b60bdd62a87852022-12-22T01:56:59ZengMDPI AGSensors1424-82202017-07-01177159210.3390/s17071592s17071592Raman Plus X: Biomedical Applications of Multimodal Raman SpectroscopyNandan K. Das0Yichuan Dai1Peng Liu2Chuanzhen Hu3Lieshu Tong4Xiaoya Chen5Zachary J. Smith6Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230027, ChinaDepartment of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230027, ChinaDepartment of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230027, ChinaDepartment of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230027, ChinaDepartment of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230027, ChinaDepartment of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230027, ChinaDepartment of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230027, ChinaRaman spectroscopy is a label-free method of obtaining detailed chemical information about samples. Its compatibility with living tissue makes it an attractive choice for biomedical analysis, yet its translation from a research tool to a clinical tool has been slow, hampered by fundamental Raman scattering issues such as long integration times and limited penetration depth. In this review we detail the how combining Raman spectroscopy with other techniques yields multimodal instruments that can help to surmount the translational barriers faced by Raman alone. We review Raman combined with several optical and non-optical methods, including fluorescence, elastic scattering, OCT, phase imaging, and mass spectrometry. In each section we highlight the power of each combination along with a brief history and presentation of representative results. Finally, we conclude with a perspective detailing both benefits and challenges for multimodal Raman measurements, and give thoughts on future directions in the field.https://www.mdpi.com/1424-8220/17/7/1592Raman spectroscopymultimodallight scattering |
| spellingShingle | Nandan K. Das Yichuan Dai Peng Liu Chuanzhen Hu Lieshu Tong Xiaoya Chen Zachary J. Smith Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy Sensors Raman spectroscopy multimodal light scattering |
| title | Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy |
| title_full | Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy |
| title_fullStr | Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy |
| title_full_unstemmed | Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy |
| title_short | Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy |
| title_sort | raman plus x biomedical applications of multimodal raman spectroscopy |
| topic | Raman spectroscopy multimodal light scattering |
| url | https://www.mdpi.com/1424-8220/17/7/1592 |
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