Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death and is the most common type of liver cancer. Due to the current paucity of drugs for HCC therapy there is a pressing need to develop new therapeutic concepts. In recent years, the role of Serum Response Factor (SRF)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/12/2540 |
| _version_ | 1797546841982631936 |
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| author | Constanze Mittermeier Andreas Konopa Susanne Muehlich |
| author_facet | Constanze Mittermeier Andreas Konopa Susanne Muehlich |
| author_sort | Constanze Mittermeier |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death and is the most common type of liver cancer. Due to the current paucity of drugs for HCC therapy there is a pressing need to develop new therapeutic concepts. In recent years, the role of Serum Response Factor (SRF) and its coactivators, Myocardin-Related Transcription Factors A and B (MRTF-A and -B), in HCC formation and progression has received considerable attention. Targeting MRTFs results in HCC growth arrest provoked by oncogene-induced senescence. The induction of senescence acts as a tumor-suppressive mechanism and therefore gains consideration for pharmacological interventions in cancer therapy. In this article, we describe the key features and the functional role of senescence in light of the development of novel drug targets for HCC therapy with a focus on MRTFs. |
| first_indexed | 2024-03-10T14:34:56Z |
| format | Article |
| id | doaj.art-5f83e2d8005749369eccfd4235f5ff44 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:34:56Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5f83e2d8005749369eccfd4235f5ff442023-11-20T22:15:33ZengMDPI AGCells2073-44092020-11-01912254010.3390/cells9122540Molecular Mechanisms to Target Cellular Senescence in Hepatocellular CarcinomaConstanze Mittermeier0Andreas Konopa1Susanne Muehlich2Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeDepartment of Chemistry and Pharmacy, Molecular and Clinical Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, GermanyDepartment of Chemistry and Pharmacy, Molecular and Clinical Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, GermanyHepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death and is the most common type of liver cancer. Due to the current paucity of drugs for HCC therapy there is a pressing need to develop new therapeutic concepts. In recent years, the role of Serum Response Factor (SRF) and its coactivators, Myocardin-Related Transcription Factors A and B (MRTF-A and -B), in HCC formation and progression has received considerable attention. Targeting MRTFs results in HCC growth arrest provoked by oncogene-induced senescence. The induction of senescence acts as a tumor-suppressive mechanism and therefore gains consideration for pharmacological interventions in cancer therapy. In this article, we describe the key features and the functional role of senescence in light of the development of novel drug targets for HCC therapy with a focus on MRTFs.https://www.mdpi.com/2073-4409/9/12/2540senescenceHCCSRFDLC1MRTFsenolytics |
| spellingShingle | Constanze Mittermeier Andreas Konopa Susanne Muehlich Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma Cells senescence HCC SRF DLC1 MRTF senolytics |
| title | Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma |
| title_full | Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma |
| title_fullStr | Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma |
| title_full_unstemmed | Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma |
| title_short | Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma |
| title_sort | molecular mechanisms to target cellular senescence in hepatocellular carcinoma |
| topic | senescence HCC SRF DLC1 MRTF senolytics |
| url | https://www.mdpi.com/2073-4409/9/12/2540 |
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