Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil
Hyptis martiusii Benth. also known as ''cidreira brava'', has some activities verified in the literature, such as antiulcerogenic, antimicrobial and antiedematogenic. This study aimed to verify the anti-inflammatory and antinociceptive effect of the leaves essential oil. For the...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Biotechnology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215017X22000546 |
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| author | Andreza G.R. Barbosa Cícera D.M.O. Tintino Renata T. Pessoa Luiz J. de Lacerda Neto Anita O.B.P.B. Martins Maria R.C. de Oliveira Henrique D.M. Coutinho Natália Cruz-Martins Lucindo J. Quintans Junior Polrat Wilairatana Irwin R.A. de Menezes |
| author_facet | Andreza G.R. Barbosa Cícera D.M.O. Tintino Renata T. Pessoa Luiz J. de Lacerda Neto Anita O.B.P.B. Martins Maria R.C. de Oliveira Henrique D.M. Coutinho Natália Cruz-Martins Lucindo J. Quintans Junior Polrat Wilairatana Irwin R.A. de Menezes |
| author_sort | Andreza G.R. Barbosa |
| collection | DOAJ |
| description | Hyptis martiusii Benth. also known as ''cidreira brava'', has some activities verified in the literature, such as antiulcerogenic, antimicrobial and antiedematogenic. This study aimed to verify the anti-inflammatory and antinociceptive effect of the leaves essential oil. For the evaluation of the anti-inflammatory activity of OEHM (100 mg/kg/p.o.), models paw edema induced by dextran and histamine, peritonitis and vascular permeability were used. Regarding the anti-nociceptive activity of the OEHM, abdominal contortion tests by acetic acid, formalin, hot plate (50.75 and 100 mg/kg/p.o.), open field and mechanical plantar hyper-nociception (100 mg/kg/p.o.) were carried out. OEHM (100 mg/kg) showed anti-inflammatory activity, being able to remarkably deducing the paw edema induced by dextran and histamine, the total number of cell leukocytes/neutrophils in peritonitis, and exudate in vascular permeability. In antinociceptive activity, the OEHM did not promote significant effect in central nervous system in the open field assay, remarkably reduced abdominal contortions (50, 75 and 100 mg/kg), the time in the formalin assay and the mechanical hyper-nociception (100 mg/kg); however, only doses between 75 and 100 mg/kg were capable of ameliorating the reponse latency time. Regarding the probable mechanism of action, the antinociceptive activity includes the participation in the activation of opioid, TRPV1, and α2-noradrenergic systems. In short, data obtained here reveal that OEHM has anti-inflammatory and antinociceptive activity, implying that its action may be involved in the mechanism of inhibition or liberation of pro-inflammatory mediators involved in pain and inflammation. |
| first_indexed | 2024-04-11T14:21:09Z |
| format | Article |
| id | doaj.art-5f844d12287a43f1905a79a7111cb67e |
| institution | Directory Open Access Journal |
| issn | 2215-017X |
| language | English |
| last_indexed | 2024-04-11T14:21:09Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biotechnology Reports |
| spelling | doaj.art-5f844d12287a43f1905a79a7111cb67e2022-12-22T04:19:03ZengElsevierBiotechnology Reports2215-017X2022-09-0135e00756Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oilAndreza G.R. Barbosa0Cícera D.M.O. Tintino1Renata T. Pessoa2Luiz J. de Lacerda Neto3Anita O.B.P.B. Martins4Maria R.C. de Oliveira5Henrique D.M. Coutinho6Natália Cruz-Martins7Lucindo J. Quintans Junior8Polrat Wilairatana9Irwin R.A. de Menezes10Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri, Rua Coronel Antônio Luis 1161, Pimenta, CEP 63105-000, Crato, Ceará, BrazilLaboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri, Rua Coronel Antônio Luis 1161, Pimenta, CEP 63105-000, Crato, Ceará, BrazilLaboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri, Rua Coronel Antônio Luis 1161, Pimenta, CEP 63105-000, Crato, Ceará, BrazilLaboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri, Rua Coronel Antônio Luis 1161, Pimenta, CEP 63105-000, Crato, Ceará, BrazilLaboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri, Rua Coronel Antônio Luis 1161, Pimenta, CEP 63105-000, Crato, Ceará, BrazilLaboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri, Rua Coronel Antônio Luis 1161, Pimenta, CEP 63105-000, Crato, Ceará, Brazil; Graduate Program in Biotechnology-Northeast Biotechnology Network (RENORBIO), State University of Ceará (UECE), Fortaleza, Ceará, BrazilLaboratory of Microbiology and Molecular Biology; Department of Biological Chemistry, Regional University of Cariri, Rua Coronel Antônio Luis 1161, Pimenta, CEP 63105-000, Crato, Ceará, Brazil; Corresponding authors.Faculty of Medicine, University of Porto, Porto, Portugal; Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal; Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra, 1317, 4585-116, Gandra PRD, Portugal; TOXRUN - Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116, Gandra, PortugalLaboratory of Neuroscience and Pharmacological Assays; Department of Physiology, Federal University of Sergipe, Avenue Marechal Rondon, S/N, CEP 49100-000, São Cristóvão, Sergipe, BrazilDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Corresponding authors.Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri, Rua Coronel Antônio Luis 1161, Pimenta, CEP 63105-000, Crato, Ceará, Brazil; Corresponding authors.Hyptis martiusii Benth. also known as ''cidreira brava'', has some activities verified in the literature, such as antiulcerogenic, antimicrobial and antiedematogenic. This study aimed to verify the anti-inflammatory and antinociceptive effect of the leaves essential oil. For the evaluation of the anti-inflammatory activity of OEHM (100 mg/kg/p.o.), models paw edema induced by dextran and histamine, peritonitis and vascular permeability were used. Regarding the anti-nociceptive activity of the OEHM, abdominal contortion tests by acetic acid, formalin, hot plate (50.75 and 100 mg/kg/p.o.), open field and mechanical plantar hyper-nociception (100 mg/kg/p.o.) were carried out. OEHM (100 mg/kg) showed anti-inflammatory activity, being able to remarkably deducing the paw edema induced by dextran and histamine, the total number of cell leukocytes/neutrophils in peritonitis, and exudate in vascular permeability. In antinociceptive activity, the OEHM did not promote significant effect in central nervous system in the open field assay, remarkably reduced abdominal contortions (50, 75 and 100 mg/kg), the time in the formalin assay and the mechanical hyper-nociception (100 mg/kg); however, only doses between 75 and 100 mg/kg were capable of ameliorating the reponse latency time. Regarding the probable mechanism of action, the antinociceptive activity includes the participation in the activation of opioid, TRPV1, and α2-noradrenergic systems. In short, data obtained here reveal that OEHM has anti-inflammatory and antinociceptive activity, implying that its action may be involved in the mechanism of inhibition or liberation of pro-inflammatory mediators involved in pain and inflammation.http://www.sciencedirect.com/science/article/pii/S2215017X22000546Hyptis martiusiiInflammationNociceptionNatural productMechanism of action |
| spellingShingle | Andreza G.R. Barbosa Cícera D.M.O. Tintino Renata T. Pessoa Luiz J. de Lacerda Neto Anita O.B.P.B. Martins Maria R.C. de Oliveira Henrique D.M. Coutinho Natália Cruz-Martins Lucindo J. Quintans Junior Polrat Wilairatana Irwin R.A. de Menezes Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil Biotechnology Reports Hyptis martiusii Inflammation Nociception Natural product Mechanism of action |
| title | Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil |
| title_full | Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil |
| title_fullStr | Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil |
| title_full_unstemmed | Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil |
| title_short | Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil |
| title_sort | anti inflammatory and antinociceptive effect of hyptis martiusii benth leaves essential oil |
| topic | Hyptis martiusii Inflammation Nociception Natural product Mechanism of action |
| url | http://www.sciencedirect.com/science/article/pii/S2215017X22000546 |
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