A bifunctional bortezomib-loaded porous nano-hydroxyapatite/alginate scaffold for simultaneous tumor inhibition and bone regeneration

A bifunctional bortezomib-loaded porous nano-hydroxyapatite/alginate scaffold for simultaneous tumor inhibition and bone regeneration

Abstract Treatments of osteolytic lesions due to malignant metastasis remain one of the major clinical challenges. The residual tumor cells after surgical resections and an acidic tumor microenvironment are unfavorable for osteogenic induction. Bortezomib (BTZ), a proteasome inhibitor used in chemot...

Full description

Bibliographic Details
Main Authors: Jiafei Chen, Junru Wen, Yike Fu, Xiang Li, Jie Huang, Xiaoxu Guan, Yi Zhou
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Nanobiotechnology
Subjects:
BTZ/nHA@SA scaffold
nHA
BTZ
Anti-tumor
Bone regeneration
Online Access:https://doi.org/10.1186/s12951-023-01940-0

Similar Items

Similar Items