Super Early Scan of PSMA PET/CT in Evaluating Primary and Metastatic Lesions of Prostate Cancer
<sup>68</sup>Ga-prostate specific membrane antigen (PSMA)-11 PET/CT has been widely used in the diagnosis of prostate cancer (PCa); however, the urine lead shielding resulting from the urinary metabolism of tracers may obstruct the detection of surrounding metastasis. In this research, t...
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MDPI AG
2022-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/14/4661 |
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| author | Juanli Mao Mingjun Gao Bin Cui Yingying Zhang Xiaojiao Wang Siyu Liang Changjing Zuo Peng Chen Aisheng Dong |
| author_facet | Juanli Mao Mingjun Gao Bin Cui Yingying Zhang Xiaojiao Wang Siyu Liang Changjing Zuo Peng Chen Aisheng Dong |
| author_sort | Juanli Mao |
| collection | DOAJ |
| description | <sup>68</sup>Ga-prostate specific membrane antigen (PSMA)-11 PET/CT has been widely used in the diagnosis of prostate cancer (PCa); however, the urine lead shielding resulting from the urinary metabolism of tracers may obstruct the detection of surrounding metastasis. In this research, the additive value of super early scanning in diagnosing primary lesions and metastasis in the pelvic cavity was evaluated. Firstly, the differentiation efficiency of <sup>68</sup>Ga-PSMA-11 PET scanned at 3 min post-injection (min P.I.) was measured in PSMA-positive (22rv1 cells) and PSMA-negative (PC3 cells) model mice. Secondly, 106 patients were scanned at 3 min P.I. for the pelvic cavity and then scanned as a standard protocol at 45 min P.I. In the results, the differential diagnosis of PSMA expression was completely reflected as early as 3 min P.I. for mice models. For patients, when correlated with the Gleason score, the quantitative results of the super early scan displayed a comparable correlation coefficient with the routine scan. The target to bladder ratios increased from 1.44 ± 2.40 at 45 min to 10.10 ± 19.10 at 3 min (<i>p</i> < 0.001) for the primary lesions, and it increased from 0.99 ± 1.88 to 9.27 ± 23.03 for metastasis. Meanwhile, the target to background ratios increased from 2.21 ± 2.44 at 3 min to 19.13 ± 23.93 at 45 min (<i>p</i> < 0.001) for the primary lesions, and it increased from 1.68 ± 2.71 to 12.04 ± 18.73 (<i>p</i> < 0.001) for metastasis. In conclusion, super early scanning of <sup>68</sup>Ga-PSMA-11 PET/CT added referable information for metastasis detection in order to avoid disturbing tracer activity in the urinary system. |
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| language | English |
| last_indexed | 2024-03-09T10:14:21Z |
| publishDate | 2022-07-01 |
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| spelling | doaj.art-5f8ac67ca4314cde9fad3bc576c4c12c2023-12-01T22:30:37ZengMDPI AGMolecules1420-30492022-07-012714466110.3390/molecules27144661Super Early Scan of PSMA PET/CT in Evaluating Primary and Metastatic Lesions of Prostate CancerJuanli Mao0Mingjun Gao1Bin Cui2Yingying Zhang3Xiaojiao Wang4Siyu Liang5Changjing Zuo6Peng Chen7Aisheng Dong8Department of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai 200433, ChinaDepartment of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai 200433, ChinaDepartment of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai 200433, ChinaDepartment of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai 200433, ChinaDepartment of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai 200433, ChinaDepartment of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai 200433, ChinaDepartment of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai 200433, ChinaDepartment of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai 200433, China<sup>68</sup>Ga-prostate specific membrane antigen (PSMA)-11 PET/CT has been widely used in the diagnosis of prostate cancer (PCa); however, the urine lead shielding resulting from the urinary metabolism of tracers may obstruct the detection of surrounding metastasis. In this research, the additive value of super early scanning in diagnosing primary lesions and metastasis in the pelvic cavity was evaluated. Firstly, the differentiation efficiency of <sup>68</sup>Ga-PSMA-11 PET scanned at 3 min post-injection (min P.I.) was measured in PSMA-positive (22rv1 cells) and PSMA-negative (PC3 cells) model mice. Secondly, 106 patients were scanned at 3 min P.I. for the pelvic cavity and then scanned as a standard protocol at 45 min P.I. In the results, the differential diagnosis of PSMA expression was completely reflected as early as 3 min P.I. for mice models. For patients, when correlated with the Gleason score, the quantitative results of the super early scan displayed a comparable correlation coefficient with the routine scan. The target to bladder ratios increased from 1.44 ± 2.40 at 45 min to 10.10 ± 19.10 at 3 min (<i>p</i> < 0.001) for the primary lesions, and it increased from 0.99 ± 1.88 to 9.27 ± 23.03 for metastasis. Meanwhile, the target to background ratios increased from 2.21 ± 2.44 at 3 min to 19.13 ± 23.93 at 45 min (<i>p</i> < 0.001) for the primary lesions, and it increased from 1.68 ± 2.71 to 12.04 ± 18.73 (<i>p</i> < 0.001) for metastasis. In conclusion, super early scanning of <sup>68</sup>Ga-PSMA-11 PET/CT added referable information for metastasis detection in order to avoid disturbing tracer activity in the urinary system.https://www.mdpi.com/1420-3049/27/14/4661super early<sup>68</sup>Ga-PSMA-11 PET/CTprostate cancerprimary lesionsmetastasis |
| spellingShingle | Juanli Mao Mingjun Gao Bin Cui Yingying Zhang Xiaojiao Wang Siyu Liang Changjing Zuo Peng Chen Aisheng Dong Super Early Scan of PSMA PET/CT in Evaluating Primary and Metastatic Lesions of Prostate Cancer Molecules super early <sup>68</sup>Ga-PSMA-11 PET/CT prostate cancer primary lesions metastasis |
| title | Super Early Scan of PSMA PET/CT in Evaluating Primary and Metastatic Lesions of Prostate Cancer |
| title_full | Super Early Scan of PSMA PET/CT in Evaluating Primary and Metastatic Lesions of Prostate Cancer |
| title_fullStr | Super Early Scan of PSMA PET/CT in Evaluating Primary and Metastatic Lesions of Prostate Cancer |
| title_full_unstemmed | Super Early Scan of PSMA PET/CT in Evaluating Primary and Metastatic Lesions of Prostate Cancer |
| title_short | Super Early Scan of PSMA PET/CT in Evaluating Primary and Metastatic Lesions of Prostate Cancer |
| title_sort | super early scan of psma pet ct in evaluating primary and metastatic lesions of prostate cancer |
| topic | super early <sup>68</sup>Ga-PSMA-11 PET/CT prostate cancer primary lesions metastasis |
| url | https://www.mdpi.com/1420-3049/27/14/4661 |
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