The study of antifungal activities of magnesium oxide and copper oxide nanoparticles against different species of Aspergillus
Background & Objective: Food can be contaminated with various fungi. The use of nanotechnology, especially metal oxides can reduce this contamination. The aim of this study was to investigate the antifungal effect of magnesium oxide and copper oxide nanoparticles against Aspergillus species that...
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2017-11-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-1324-en.pdf |
| _version_ | 1797679623752908800 |
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| author | Nader Habibi Hamidreza Gheisari Mahmood Aminlari Fatemeh Sedaghati |
| author_facet | Nader Habibi Hamidreza Gheisari Mahmood Aminlari Fatemeh Sedaghati |
| author_sort | Nader Habibi |
| collection | DOAJ |
| description | Background & Objective: Food can be contaminated with various fungi. The use of nanotechnology, especially metal oxides can reduce this contamination. The aim of this study was to investigate the antifungal effect of magnesium oxide and copper oxide nanoparticles against Aspergillus species that are important in food hygiene.
Materials & Methods: Magnesium oxide and copper oxide nanoparticles were synthesized chemically, then their morphology and size were investigated by transmission electron microscopy, scanning electron microscopy, X-ray diffraction and zetasizer. MIC and MFC of these nanoparticles against Aspergillus species were examined individually and in combination with each other by micro dilution method in saboraud dextrose broth and saboraud dextrose agar media and FIC was calculated.
Results: The size of nanoparticles was between 10 to 60 nm. They had different forms and high purity. The mean MIC and MFC values of magnesium oxide nanoparticles for the species of A. flavus, A. fumigatus, A. niger and A. parasiticus were 10.1 and 10.31 mg/ml, respectively. These values for copper oxide nanoparticles were 10.25 and 10.08, respectively. Most inhibitory and fungicidal effect of these nanoparticles was on A. niger and A. fumigatus respectively. Since FIC index was greater than 1, there was no interaction. The mean MIC value of the two nanoparticles combination was 9.49 mg/ml.
Conclusions: This study showed that each of magnesium oxide or copper oxide nanoparticles as anti-fungal substances could have inhibitory and fungicidal properties individually, but their combination do not have any interacting effect. |
| first_indexed | 2024-03-11T23:17:29Z |
| format | Article |
| id | doaj.art-5f8b89a3d6034984a5fa1ef5a7afa337 |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:29Z |
| publishDate | 2017-11-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-5f8b89a3d6034984a5fa1ef5a7afa3372023-09-20T21:23:18ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232017-11-0173317327The study of antifungal activities of magnesium oxide and copper oxide nanoparticles against different species of AspergillusNader Habibi0Hamidreza Gheisari1Mahmood Aminlari2Fatemeh Sedaghati3 Department Food Hygiene, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Department Food Hygiene, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Department Food Hygiene, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Department Chemistry, Estahban High Education Center, Estahban, Iran Background & Objective: Food can be contaminated with various fungi. The use of nanotechnology, especially metal oxides can reduce this contamination. The aim of this study was to investigate the antifungal effect of magnesium oxide and copper oxide nanoparticles against Aspergillus species that are important in food hygiene. Materials & Methods: Magnesium oxide and copper oxide nanoparticles were synthesized chemically, then their morphology and size were investigated by transmission electron microscopy, scanning electron microscopy, X-ray diffraction and zetasizer. MIC and MFC of these nanoparticles against Aspergillus species were examined individually and in combination with each other by micro dilution method in saboraud dextrose broth and saboraud dextrose agar media and FIC was calculated. Results: The size of nanoparticles was between 10 to 60 nm. They had different forms and high purity. The mean MIC and MFC values of magnesium oxide nanoparticles for the species of A. flavus, A. fumigatus, A. niger and A. parasiticus were 10.1 and 10.31 mg/ml, respectively. These values for copper oxide nanoparticles were 10.25 and 10.08, respectively. Most inhibitory and fungicidal effect of these nanoparticles was on A. niger and A. fumigatus respectively. Since FIC index was greater than 1, there was no interaction. The mean MIC value of the two nanoparticles combination was 9.49 mg/ml. Conclusions: This study showed that each of magnesium oxide or copper oxide nanoparticles as anti-fungal substances could have inhibitory and fungicidal properties individually, but their combination do not have any interacting effect.http://jabs.fums.ac.ir/article-1-1324-en.pdfnanoparticlemagnesium oxidecopper oxideaspergillusmicmfc |
| spellingShingle | Nader Habibi Hamidreza Gheisari Mahmood Aminlari Fatemeh Sedaghati The study of antifungal activities of magnesium oxide and copper oxide nanoparticles against different species of Aspergillus Journal of Advanced Biomedical Sciences nanoparticle magnesium oxide copper oxide aspergillus mic mfc |
| title | The study of antifungal activities of magnesium oxide and copper oxide nanoparticles against different species of Aspergillus |
| title_full | The study of antifungal activities of magnesium oxide and copper oxide nanoparticles against different species of Aspergillus |
| title_fullStr | The study of antifungal activities of magnesium oxide and copper oxide nanoparticles against different species of Aspergillus |
| title_full_unstemmed | The study of antifungal activities of magnesium oxide and copper oxide nanoparticles against different species of Aspergillus |
| title_short | The study of antifungal activities of magnesium oxide and copper oxide nanoparticles against different species of Aspergillus |
| title_sort | study of antifungal activities of magnesium oxide and copper oxide nanoparticles against different species of aspergillus |
| topic | nanoparticle magnesium oxide copper oxide aspergillus mic mfc |
| url | http://jabs.fums.ac.ir/article-1-1324-en.pdf |
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