Biological basis of extensive pleiotropy between blood traits and cancer risk

Biological basis of extensive pleiotropy between blood traits and cancer risk

Abstract Background The immune system has a central role in preventing carcinogenesis. Alteration of systemic immune cell levels may increase cancer risk. However, the extent to which common genetic variation influences blood traits and cancer risk remains largely undetermined. Here, we identify ple...

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Bibliographic Details
Main Authors: Miguel Angel Pardo-Cea, Xavier Farré, Anna Esteve, Joanna Palade, Roderic Espín, Francesca Mateo, Eric Alsop, Marc Alorda, Natalia Blay, Alexandra Baiges, Arzoo Shabbir, Francesc Comellas, Antonio Gómez, Montserrat Arnan, Alex Teulé, Monica Salinas, Laura Berrocal, Joan Brunet, Paula Rofes, Conxi Lázaro, Miquel Conesa, Juan Jose Rojas, Lars Velten, Wojciech Fendler, Urszula Smyczynska, Dipanjan Chowdhury, Yong Zeng, Housheng Hansen He, Rong Li, Kendall Van Keuren-Jensen, Rafael de Cid, Miquel Angel Pujana
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Genome Medicine
Subjects:
Blood trait
Cancer
Eosinophil
Hematopoiesis
Myeloid
Pleiotropy
Online Access:https://doi.org/10.1186/s13073-024-01294-8

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