Mcl-1 deficiency in murine livers leads to nuclear polyploidisation and mitotic errors: Implications for hepatocellular carcinoma

Mcl-1 deficiency in murine livers leads to nuclear polyploidisation and mitotic errors: Implications for hepatocellular carcinoma

Background & Aims: Mcl-1, an antiapoptotic protein overexpressed in many tumours, including hepatocellular carcinoma (HCC), represents a promising target for cancer treatment. Although Mcl-1 non-apoptotic roles might critically influence the therapeutic potential of Mcl-1 inhibitors, these f...

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Bibliographic Details
Main Authors: Laure-Alix Clerbaux, Pierre Cordier, Nina Desboeufs, Kristian Unger, Peter Leary, Gabriel Semere, Yannick Boege, Lap Kwan Chan, Chantal Desdouets, Massimo Lopes, Achim Weber
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:JHEP Reports
Subjects:
Liver
Polyploidy
Mcl-1
Chromosome segregation
Mutational signature
Hepatocarcinogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923001696

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