AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway

AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway

Abstract Background The actin filament-associated protein (AFAP) family genes include AFAP1/AFAP-110, AFAP1L1 and AFAP1L2/XB130. Increasing evidence indicates these three AFAP family members participate in tumor progression, but their clinical significance and molecular mechanisms in gastric cancer...

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Bibliographic Details
Main Authors: Bo Sun, Bai Ding, Yu Chen, Chuang Peng, Xu Chen
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Translational Medicine
Subjects:
Actin filament associated protein 1 like 1
Epithelial-mesenchymal transition
Gastric cancer
Integrin subunit alpha 5
Online Access:https://doi.org/10.1186/s12967-023-03871-8

Internet

https://doi.org/10.1186/s12967-023-03871-8

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