Evaluation of anticancer activity of Plumbago indica root extract on cervical HeLa cancer cells
Plumbago indica L. has a various pharmacological activity; however, the anticancer activity in cervical cancer has less information. To examine the antiproliferative, apoptotic, and antimigratory activity of Plumbago indica root extract on cervical cancer cells. The extract of P. indica was explore...
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Format: | Article |
Language: | English |
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AcademicPres
2023-09-01
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Series: | Notulae Botanicae Horti Agrobotanici Cluj-Napoca |
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Online Access: | https://www.notulaebotanicae.ro/index.php/nbha/article/view/12990 |
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author | Benjaporn BURANRAT Pornpimon WONGSUWAN Wichuda PHIPHITPHIBUNSUK |
author_facet | Benjaporn BURANRAT Pornpimon WONGSUWAN Wichuda PHIPHITPHIBUNSUK |
author_sort | Benjaporn BURANRAT |
collection | DOAJ |
description |
Plumbago indica L. has a various pharmacological activity; however, the anticancer activity in cervical cancer has less information. To examine the antiproliferative, apoptotic, and antimigratory activity of Plumbago indica root extract on cervical cancer cells. The extract of P. indica was explored for cell viability, apoptosis, and migration by sulforhodamine B, colony formation, cell cycle distribution, Wound healing, Annexin V-FITC staining apoptotic, mitochondrial function, and reactive oxygen species (ROS) formation. The data indicated that P. indica extract suppressed HeLa cervical cells viability by dose- and time-dependent manner along with the reduction of cancer cell number and colony forming ability. After 48 h of incubation period, the PR extract exhibited a significant reduction of migratory ability by dose-dependent manner. Furthermore, these extracts significantly showed a reduction of cell viability along with induction of late apoptosis. The mechanism of action was shown by detecting mitochondrial dysfunction and activating of ROS formation on HeLa cells-treated with P. indica extract. The extract of P. indica has a growth inhibition, migratory suppression, and apoptotic induction. The extract has an anticancer activity by reducing mitochondrial function and activating ROS formation.
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first_indexed | 2024-03-11T21:04:33Z |
format | Article |
id | doaj.art-5f901bbc417f440c98f85dc459cb2f8e |
institution | Directory Open Access Journal |
issn | 0255-965X 1842-4309 |
language | English |
last_indexed | 2024-03-11T21:04:33Z |
publishDate | 2023-09-01 |
publisher | AcademicPres |
record_format | Article |
series | Notulae Botanicae Horti Agrobotanici Cluj-Napoca |
spelling | doaj.art-5f901bbc417f440c98f85dc459cb2f8e2023-09-29T14:37:52ZengAcademicPresNotulae Botanicae Horti Agrobotanici Cluj-Napoca0255-965X1842-43092023-09-0151310.15835/nbha51312990Evaluation of anticancer activity of Plumbago indica root extract on cervical HeLa cancer cellsBenjaporn BURANRAT0Pornpimon WONGSUWAN1Wichuda PHIPHITPHIBUNSUK2Mahasarakham University, Faculty of Medicine, Talat, Muang district, Maha Sarakham, 44000 Mahasarakham University, Faculty of Medicine, Talat, Muang district, Maha Sarakham, 44000University of Phayao, School of Pharmaceutical Sciences, Department of Pharmaceutical Care, Phayao 56000 Plumbago indica L. has a various pharmacological activity; however, the anticancer activity in cervical cancer has less information. To examine the antiproliferative, apoptotic, and antimigratory activity of Plumbago indica root extract on cervical cancer cells. The extract of P. indica was explored for cell viability, apoptosis, and migration by sulforhodamine B, colony formation, cell cycle distribution, Wound healing, Annexin V-FITC staining apoptotic, mitochondrial function, and reactive oxygen species (ROS) formation. The data indicated that P. indica extract suppressed HeLa cervical cells viability by dose- and time-dependent manner along with the reduction of cancer cell number and colony forming ability. After 48 h of incubation period, the PR extract exhibited a significant reduction of migratory ability by dose-dependent manner. Furthermore, these extracts significantly showed a reduction of cell viability along with induction of late apoptosis. The mechanism of action was shown by detecting mitochondrial dysfunction and activating of ROS formation on HeLa cells-treated with P. indica extract. The extract of P. indica has a growth inhibition, migratory suppression, and apoptotic induction. The extract has an anticancer activity by reducing mitochondrial function and activating ROS formation. https://www.notulaebotanicae.ro/index.php/nbha/article/view/12990apoptosiscell cycle arrestcervical cancer cellsmigrationmitochondrial dysfunctionPlumbago indica |
spellingShingle | Benjaporn BURANRAT Pornpimon WONGSUWAN Wichuda PHIPHITPHIBUNSUK Evaluation of anticancer activity of Plumbago indica root extract on cervical HeLa cancer cells Notulae Botanicae Horti Agrobotanici Cluj-Napoca apoptosis cell cycle arrest cervical cancer cells migration mitochondrial dysfunction Plumbago indica |
title | Evaluation of anticancer activity of Plumbago indica root extract on cervical HeLa cancer cells |
title_full | Evaluation of anticancer activity of Plumbago indica root extract on cervical HeLa cancer cells |
title_fullStr | Evaluation of anticancer activity of Plumbago indica root extract on cervical HeLa cancer cells |
title_full_unstemmed | Evaluation of anticancer activity of Plumbago indica root extract on cervical HeLa cancer cells |
title_short | Evaluation of anticancer activity of Plumbago indica root extract on cervical HeLa cancer cells |
title_sort | evaluation of anticancer activity of plumbago indica root extract on cervical hela cancer cells |
topic | apoptosis cell cycle arrest cervical cancer cells migration mitochondrial dysfunction Plumbago indica |
url | https://www.notulaebotanicae.ro/index.php/nbha/article/view/12990 |
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