The Hyperpolarization-Activated Cyclic-Nucleotide-Gated Channel Blocker Ivabradine Does Not Prevent Arrhythmias in Catecholaminergic Polymorphic Ventricular Tachycardia

The Hyperpolarization-Activated Cyclic-Nucleotide-Gated Channel Blocker Ivabradine Does Not Prevent Arrhythmias in Catecholaminergic Polymorphic Ventricular Tachycardia

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, stressed-provoked ventricular arrhythmia. CPVT is treated by β-adrenergic receptor blockers, Na+ channel inhibitors, sympathetic denervation, or by implanting a defibrillator. We showed recently that blockers of SK4 Ca2+-a...

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Bibliographic Details
Main Authors: Hanna Bueno-Levy, David Weisbrod, Dor Yadin, Shiraz Haron-Khun, Asher Peretz, Edith Hochhauser, Michael Arad, Bernard Attali
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
ivabradine
SK4
potassium channel
catecholaminergic polymorphic ventricular tachycardia
cardiac arrhythmia
ventricular arrhythmias
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01566/full

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