Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil
In August 1983,85 inhabitants of the municipality of Humaitá, Amazonas State, Brazil were studied to determine the prevalence of antigens to HLA-A, -B, -C and DR. Thirty-eight were sick with malaria due to Plasmodium falciparum. All subjects were examined for splenomegaly, blood parasitaemia and ant...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
1987-09-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821987000300005&lng=en&tlng=en |
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| author | Domingos Alves Meira Jordão Pellegrino Júnior Jussara Marcondes-Machado Kimiyoski Tsuji Elinda Satie Matsuoka Elizete Haida Albert Boutros El Khoury |
| author_facet | Domingos Alves Meira Jordão Pellegrino Júnior Jussara Marcondes-Machado Kimiyoski Tsuji Elinda Satie Matsuoka Elizete Haida Albert Boutros El Khoury |
| author_sort | Domingos Alves Meira |
| collection | DOAJ |
| description | In August 1983,85 inhabitants of the municipality of Humaitá, Amazonas State, Brazil were studied to determine the prevalence of antigens to HLA-A, -B, -C and DR. Thirty-eight were sick with malaria due to Plasmodium falciparum. All subjects were examined for splenomegaly, blood parasitaemia and antibodies to malaria. They constituted three groups: 1) 25 subjects native to the Amazon region who had never had malaria; 2) 38 Amazonian subjects who had malaria in the past or currently had an infection; 3) 22 patients with malaria who had acquired the infection in the Amazon Region but came from other regions of Brazil. Blood was taken from each person, the lymphocytes were separated and typed by the test of microlymphocytotoxicity. There was a high frequency of antigens that could not be identified in the groups studied which suggests the existence of a homozygote or phenotype not identified in the population. There was a high frequency of the phenotype Ag(W24) (44.7%) in group 2 when compared with group 1 (32%) or group 3 (9%). Also the individuals in group 2 showed an elevated frequency of antigen DR(4)80%) when compared with group 1 (36.6%) or group 3 (16.6%). These observations suggest the possibility of a genetic susceptibility to malaria among Amazonian residents and indicate a necessity for more extensive studies of the frequency of HLA antigens among inhabitants of this endemic malarial zone. |
| first_indexed | 2024-04-13T17:46:54Z |
| format | Article |
| id | doaj.art-5f92c337f85f4ccab7af3295046047e7 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T17:46:54Z |
| publishDate | 1987-09-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-5f92c337f85f4ccab7af3295046047e72022-12-22T02:36:55ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98491987-09-0120315315810.1590/S0037-86821987000300005S0037-86821987000300005Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, BrazilDomingos Alves Meira0Jordão Pellegrino Júnior1Jussara Marcondes-Machado2Kimiyoski Tsuji3Elinda Satie Matsuoka4Elizete Haida5Albert Boutros El Khoury6Universidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaTokai UniversityHospital do Servidor Público Estadual Francisco Morato de OliveiraHospital do Servidor Público Estadual Francisco Morato de OliveiraHospital do Servidor Público Estadual Francisco Morato de OliveiraIn August 1983,85 inhabitants of the municipality of Humaitá, Amazonas State, Brazil were studied to determine the prevalence of antigens to HLA-A, -B, -C and DR. Thirty-eight were sick with malaria due to Plasmodium falciparum. All subjects were examined for splenomegaly, blood parasitaemia and antibodies to malaria. They constituted three groups: 1) 25 subjects native to the Amazon region who had never had malaria; 2) 38 Amazonian subjects who had malaria in the past or currently had an infection; 3) 22 patients with malaria who had acquired the infection in the Amazon Region but came from other regions of Brazil. Blood was taken from each person, the lymphocytes were separated and typed by the test of microlymphocytotoxicity. There was a high frequency of antigens that could not be identified in the groups studied which suggests the existence of a homozygote or phenotype not identified in the population. There was a high frequency of the phenotype Ag(W24) (44.7%) in group 2 when compared with group 1 (32%) or group 3 (9%). Also the individuals in group 2 showed an elevated frequency of antigen DR(4)80%) when compared with group 1 (36.6%) or group 3 (16.6%). These observations suggest the possibility of a genetic susceptibility to malaria among Amazonian residents and indicate a necessity for more extensive studies of the frequency of HLA antigens among inhabitants of this endemic malarial zone.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821987000300005&lng=en&tlng=enMaláriaPlasmodium falciparumPrevalência de HLA |
| spellingShingle | Domingos Alves Meira Jordão Pellegrino Júnior Jussara Marcondes-Machado Kimiyoski Tsuji Elinda Satie Matsuoka Elizete Haida Albert Boutros El Khoury Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil Revista da Sociedade Brasileira de Medicina Tropical Malária Plasmodium falciparum Prevalência de HLA |
| title | Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_full | Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_fullStr | Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_full_unstemmed | Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_short | Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_sort | frequency of human leukocyte antigen hla in patients with malaria and in the general population of humaita county amazonas state brazil |
| topic | Malária Plasmodium falciparum Prevalência de HLA |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821987000300005&lng=en&tlng=en |
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