High-grade tumor budding is a risk factor for survival in patients with laryngeal squamous cell carcinoma
Objective: With the increasing incidence and mortality of laryngeal squamous cell carcinoma worldwide, researchers continue to search for novel prognostic factors and treatment methods for preventing early laryngeal squamous cell carcinoma from becoming advanced laryngeal squamous cell carcinoma. Th...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Brazilian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1808869423000782 |
| _version_ | 1797683067514519552 |
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| author | Li Luo Honggang Liu |
| author_facet | Li Luo Honggang Liu |
| author_sort | Li Luo |
| collection | DOAJ |
| description | Objective: With the increasing incidence and mortality of laryngeal squamous cell carcinoma worldwide, researchers continue to search for novel prognostic factors and treatment methods for preventing early laryngeal squamous cell carcinoma from becoming advanced laryngeal squamous cell carcinoma. This study aims to determine if tumor budding is an independent risk factor associated with the survival of patients with laryngeal squamous cell carcinoma. Methods: 268 cases of laryngeal squamous cell carcinoma were studied, and tumor budding was analyzed for associations with clinicopathological features and clinical outcomes. Results: Tumor budding was divided into low-grade tumor budding (0–6/0.785 mm2) and high-grade tumor budding (≥7/0.785 mm2) based on the results of the receiver operating characteristics curve analysis. Logistic regression analysis showed that smaller tumor cell nests, the low levels of tumor-infiltrating lymphocytes, and higher pathological T staging were the risk factors for high-grade tumor budding (p < 0.05). In the low-grade tumor budding group, there was no statistic difference in survival between patients without tumor budding and those with 1–6/0.785 mm2 tumor budding. Multivariate survival analysis showed high-grade tumor budding (p < 0.001) was independent prognostic factors for disease-free survival and overall survival in laryngeal squamous cell carcinoma. High-grade tumor budding was also an independent prognostic factor for disease-free survival (p = 0.037) and overall survival (p = 0.009) in T1-2N0 laryngeal squamous cell carcinoma. Conclusions: Smaller tumor cell nests, the low levels of tumor-infiltrating lymphocytes, and higher pathological T staging were closely associated with high-grade tumor budding in laryngeal squamous cell carcinoma. High-grade tumor budding may be an adverse risk factor that affects not only the disease-free survival and overall survival of laryngeal squamous cell carcinoma patients but also the survival of T1-2N0 laryngeal squamous cell carcinoma patients. Level of Evidence: Level 4. |
| first_indexed | 2024-03-12T00:09:06Z |
| format | Article |
| id | doaj.art-5f930fd74faa49c5b69290502cce4826 |
| institution | Directory Open Access Journal |
| issn | 1808-8694 |
| language | English |
| last_indexed | 2024-03-12T00:09:06Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj.art-5f930fd74faa49c5b69290502cce48262023-09-16T05:30:28ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86942023-09-01895101310High-grade tumor budding is a risk factor for survival in patients with laryngeal squamous cell carcinomaLi Luo0Honggang Liu1Capital Medical University, Beijing Tongren Hospital, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Department of Pathology, Beijing, China; Capital Medical University, Beijing Luhe Hospital, Department of Pathology, Beijing, ChinaCapital Medical University, Beijing Tongren Hospital, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Department of Pathology, Beijing, China; Corresponding author.Objective: With the increasing incidence and mortality of laryngeal squamous cell carcinoma worldwide, researchers continue to search for novel prognostic factors and treatment methods for preventing early laryngeal squamous cell carcinoma from becoming advanced laryngeal squamous cell carcinoma. This study aims to determine if tumor budding is an independent risk factor associated with the survival of patients with laryngeal squamous cell carcinoma. Methods: 268 cases of laryngeal squamous cell carcinoma were studied, and tumor budding was analyzed for associations with clinicopathological features and clinical outcomes. Results: Tumor budding was divided into low-grade tumor budding (0–6/0.785 mm2) and high-grade tumor budding (≥7/0.785 mm2) based on the results of the receiver operating characteristics curve analysis. Logistic regression analysis showed that smaller tumor cell nests, the low levels of tumor-infiltrating lymphocytes, and higher pathological T staging were the risk factors for high-grade tumor budding (p < 0.05). In the low-grade tumor budding group, there was no statistic difference in survival between patients without tumor budding and those with 1–6/0.785 mm2 tumor budding. Multivariate survival analysis showed high-grade tumor budding (p < 0.001) was independent prognostic factors for disease-free survival and overall survival in laryngeal squamous cell carcinoma. High-grade tumor budding was also an independent prognostic factor for disease-free survival (p = 0.037) and overall survival (p = 0.009) in T1-2N0 laryngeal squamous cell carcinoma. Conclusions: Smaller tumor cell nests, the low levels of tumor-infiltrating lymphocytes, and higher pathological T staging were closely associated with high-grade tumor budding in laryngeal squamous cell carcinoma. High-grade tumor budding may be an adverse risk factor that affects not only the disease-free survival and overall survival of laryngeal squamous cell carcinoma patients but also the survival of T1-2N0 laryngeal squamous cell carcinoma patients. Level of Evidence: Level 4.http://www.sciencedirect.com/science/article/pii/S1808869423000782Laryngeal squamous cell carcinomaTumor buddingT1-2N0Prognosis |
| spellingShingle | Li Luo Honggang Liu High-grade tumor budding is a risk factor for survival in patients with laryngeal squamous cell carcinoma Brazilian Journal of Otorhinolaryngology Laryngeal squamous cell carcinoma Tumor budding T1-2N0 Prognosis |
| title | High-grade tumor budding is a risk factor for survival in patients with laryngeal squamous cell carcinoma |
| title_full | High-grade tumor budding is a risk factor for survival in patients with laryngeal squamous cell carcinoma |
| title_fullStr | High-grade tumor budding is a risk factor for survival in patients with laryngeal squamous cell carcinoma |
| title_full_unstemmed | High-grade tumor budding is a risk factor for survival in patients with laryngeal squamous cell carcinoma |
| title_short | High-grade tumor budding is a risk factor for survival in patients with laryngeal squamous cell carcinoma |
| title_sort | high grade tumor budding is a risk factor for survival in patients with laryngeal squamous cell carcinoma |
| topic | Laryngeal squamous cell carcinoma Tumor budding T1-2N0 Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S1808869423000782 |
| work_keys_str_mv | AT liluo highgradetumorbuddingisariskfactorforsurvivalinpatientswithlaryngealsquamouscellcarcinoma AT honggangliu highgradetumorbuddingisariskfactorforsurvivalinpatientswithlaryngealsquamouscellcarcinoma |