Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis
A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Su...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2016-10-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/448071 |
| _version_ | 1819141793906688000 |
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| author | Gustavo Gomez Shifa Umar Mohammad Bilal Cristina Strahotin Kofi Clarke |
| author_facet | Gustavo Gomez Shifa Umar Mohammad Bilal Cristina Strahotin Kofi Clarke |
| author_sort | Gustavo Gomez |
| collection | DOAJ |
| description | A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. Clinicians should be aware of this potential life-threatening inflixmab side effect previously unreported in adults with UC. |
| first_indexed | 2024-12-22T12:00:06Z |
| format | Article |
| id | doaj.art-5f94ce40d70d40dcaba2f16fc41c9c56 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-22T12:00:06Z |
| publishDate | 2016-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-5f94ce40d70d40dcaba2f16fc41c9c562022-12-21T18:26:39ZengKarger PublishersCase Reports in Gastroenterology1662-06312016-10-0110359659910.1159/000448071448071Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative ColitisGustavo GomezShifa UmarMohammad BilalCristina StrahotinKofi ClarkeA 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. Clinicians should be aware of this potential life-threatening inflixmab side effect previously unreported in adults with UC.http://www.karger.com/Article/FullText/448071Febrile neutropeniaThrombocytopeniaUlcerative colitisInfliximab |
| spellingShingle | Gustavo Gomez Shifa Umar Mohammad Bilal Cristina Strahotin Kofi Clarke Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis Case Reports in Gastroenterology Febrile neutropenia Thrombocytopenia Ulcerative colitis Infliximab |
| title | Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis |
| title_full | Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis |
| title_fullStr | Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis |
| title_full_unstemmed | Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis |
| title_short | Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis |
| title_sort | febrile neutropenia with thrombocytopenia after infliximab induction in a patient with ulcerative colitis |
| topic | Febrile neutropenia Thrombocytopenia Ulcerative colitis Infliximab |
| url | http://www.karger.com/Article/FullText/448071 |
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