Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing

Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing

In melanoma, the lymphocytic infiltrate is a prognostic parameter classified morphologically into ‘brisk’, ‘non-brisk’ and ‘absent’ entailing a functional association that has never been proved. Recently, it has been shown that lymphocytic populations can be very heterogeneous, and that anti-PD-1 im...

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Bibliographic Details
Main Authors: Francesca Maria Bosisio, Asier Antoranz, Yannick van Herck, Maddalena Maria Bolognesi, Lukas Marcelis, Clizia Chinello, Jasper Wouters, Fulvio Magni, Leonidas Alexopoulos, Marguerite Stas, Veerle Boecxstaens, Oliver Bechter, Giorgio Cattoretti, Joost van den Oord
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
melanoma
multiplex
tumor-infiltrating lymphocytes
TILs
microenvironment
brisk
Online Access:https://elifesciences.org/articles/53008

Internet

https://elifesciences.org/articles/53008

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