Association of a haplotype in the NRG1 gene with schizophrenia: a case-control study
Schizophrenia (SZ) is a severe multifactorial disease. NRG1 is a gene acting in the development of SZ. A number of NRG1 single nucleotide polymorphisms (SNPs) and their haplotypes are associated with SZ. In the present study, we investigated the association of a NRG1 haplotype (G-C in rs6988339-rs37...
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Format: | Article |
Language: | English |
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De Gruyter
2023-05-01
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Series: | Türk Biyokimya Dergisi |
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Online Access: | https://doi.org/10.1515/tjb-2022-0233 |
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author | Sözen Mustafa Mert Kartalcı Şükrü |
author_facet | Sözen Mustafa Mert Kartalcı Şükrü |
author_sort | Sözen Mustafa Mert |
collection | DOAJ |
description | Schizophrenia (SZ) is a severe multifactorial disease. NRG1 is a gene acting in the development of SZ. A number of NRG1 single nucleotide polymorphisms (SNPs) and their haplotypes are associated with SZ. In the present study, we investigated the association of a NRG1 haplotype (G-C in rs6988339-rs3757930 frame) which was reported to be associated with SZ, and two other SNPs in the same gene (rs74942016, rs80127039) whose rare missense alleles were found in SZ patients. Also, we analyzed disease associations of potential new haplotypes constructed by the variants of these SNPs. |
first_indexed | 2024-03-12T22:07:03Z |
format | Article |
id | doaj.art-5f953f91da9b4bde96e5e63f94f778de |
institution | Directory Open Access Journal |
issn | 1303-829X |
language | English |
last_indexed | 2024-03-12T22:07:03Z |
publishDate | 2023-05-01 |
publisher | De Gruyter |
record_format | Article |
series | Türk Biyokimya Dergisi |
spelling | doaj.art-5f953f91da9b4bde96e5e63f94f778de2023-07-24T11:19:38ZengDe GruyterTürk Biyokimya Dergisi1303-829X2023-05-0148324625610.1515/tjb-2022-0233Association of a haplotype in the NRG1 gene with schizophrenia: a case-control studySözen Mustafa Mert0Kartalcı Şükrü1Faculty of Science and Literature, Department of Molecular Biology and Genetics, Bioinformatics Section, Inonu University, Malatya, TürkiyeFaculty of Medicine, Department of Psychiatry, Inonu University, Malatya, TürkiyeSchizophrenia (SZ) is a severe multifactorial disease. NRG1 is a gene acting in the development of SZ. A number of NRG1 single nucleotide polymorphisms (SNPs) and their haplotypes are associated with SZ. In the present study, we investigated the association of a NRG1 haplotype (G-C in rs6988339-rs3757930 frame) which was reported to be associated with SZ, and two other SNPs in the same gene (rs74942016, rs80127039) whose rare missense alleles were found in SZ patients. Also, we analyzed disease associations of potential new haplotypes constructed by the variants of these SNPs.https://doi.org/10.1515/tjb-2022-0233associationdiplotypegenetic associationgeneticshaplotypeneuregulin-1nrg1schizophreniasnp |
spellingShingle | Sözen Mustafa Mert Kartalcı Şükrü Association of a haplotype in the NRG1 gene with schizophrenia: a case-control study Türk Biyokimya Dergisi association diplotype genetic association genetics haplotype neuregulin-1 nrg1 schizophrenia snp |
title | Association of a haplotype in the NRG1 gene with schizophrenia: a case-control study |
title_full | Association of a haplotype in the NRG1 gene with schizophrenia: a case-control study |
title_fullStr | Association of a haplotype in the NRG1 gene with schizophrenia: a case-control study |
title_full_unstemmed | Association of a haplotype in the NRG1 gene with schizophrenia: a case-control study |
title_short | Association of a haplotype in the NRG1 gene with schizophrenia: a case-control study |
title_sort | association of a haplotype in the nrg1 gene with schizophrenia a case control study |
topic | association diplotype genetic association genetics haplotype neuregulin-1 nrg1 schizophrenia snp |
url | https://doi.org/10.1515/tjb-2022-0233 |
work_keys_str_mv | AT sozenmustafamert associationofahaplotypeinthenrg1genewithschizophreniaacasecontrolstudy AT kartalcısukru associationofahaplotypeinthenrg1genewithschizophreniaacasecontrolstudy |