Sensitivity Patterns of Bacterial Pathogens Isolated from Blood Cultures of Under-Five Children with Pneumonia and Clinical Sepsis
Treatment options for pneumonia and sepsis by antibiotics are limited due to the development of multidrug-resistant bacterial strains. This unmatched case-control study determined the antibiotic sensitivity against bacterial isolates obtained from septic and nonseptic children with pneumonia. Childr...
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MDPI AG
2021-05-01
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author | Sufia Islam Ashiqur Rahman Akand Tasnova Tasnim Nova Christian Lehmann Mohammod Jobayer Chisti |
author_facet | Sufia Islam Ashiqur Rahman Akand Tasnova Tasnim Nova Christian Lehmann Mohammod Jobayer Chisti |
author_sort | Sufia Islam |
collection | DOAJ |
description | Treatment options for pneumonia and sepsis by antibiotics are limited due to the development of multidrug-resistant bacterial strains. This unmatched case-control study determined the antibiotic sensitivity against bacterial isolates obtained from septic and nonseptic children with pneumonia. Children of either sex aged 0–59 months with a history of cough or shortness of breath and radiologically confirmed pneumonia were enrolled in this study. Cases with clinical signs of sepsis at admission (<i>n</i> = 151) were compared to cases without sepsis as controls (<i>n</i> = 107). A total of 205 children had a performance of blood culture, with 123 children suffering from clinical sepsis. Blood cultures showed bacterial growth in 19% of the septic samples, with 8% coagulase-negative <i>staphylococci</i> and 2.4% <i>Acinetobacter</i> species. Only 1.6% of the cases were infected by <i>Streptococcus pneumonia</i>, <i>Haemophilus influenzae</i>, <i>Salmonella typhi</i> and <i>Klebsiella</i>. In contrast, children without sepsis presented positive blood cultures with growth of <i>Salmonella typhi</i> in 2.4% of the cases and growth of <i>Klebsiella</i> in 1.2%. Bacteria were sensitive to imipenem in 100% of the cases (86% for meropenem, 83% for ceftazidime and 76% for ciprofloxacin). The mortality rate was significantly higher in children with pneumonia complicated by sepsis (odds ratio (OR) = 3.02, 95% confidence interval (CI), 1.11–8.64, <i>p</i> < 0.027). Knowledge about specific laboratory characteristics in children with pneumonia will facilitate an early diagnosis and treatment of sepsis and reduce mortality. |
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spelling | doaj.art-5f97c51605724cefbcf01b77b15161782023-11-21T20:10:14ZengMDPI AGLife2075-17292021-05-0111545010.3390/life11050450Sensitivity Patterns of Bacterial Pathogens Isolated from Blood Cultures of Under-Five Children with Pneumonia and Clinical SepsisSufia Islam0Ashiqur Rahman Akand1Tasnova Tasnim Nova2Christian Lehmann3Mohammod Jobayer Chisti4Department of Pharmacy, East West University, Dhaka 1212, BangladeshDepartment of Pharmacy, East West University, Dhaka 1212, BangladeshDepartment of Pharmacy, East West University, Dhaka 1212, BangladeshDepartment of Anesthesia, Pain Management and Perioperative Medicine, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 1X5, CanadaInternational Centre for Diarrhoeal Disease Research, Bangladesh, Nutrition & Clinical Services Division, Dhaka 1212, BangladeshTreatment options for pneumonia and sepsis by antibiotics are limited due to the development of multidrug-resistant bacterial strains. This unmatched case-control study determined the antibiotic sensitivity against bacterial isolates obtained from septic and nonseptic children with pneumonia. Children of either sex aged 0–59 months with a history of cough or shortness of breath and radiologically confirmed pneumonia were enrolled in this study. Cases with clinical signs of sepsis at admission (<i>n</i> = 151) were compared to cases without sepsis as controls (<i>n</i> = 107). A total of 205 children had a performance of blood culture, with 123 children suffering from clinical sepsis. Blood cultures showed bacterial growth in 19% of the septic samples, with 8% coagulase-negative <i>staphylococci</i> and 2.4% <i>Acinetobacter</i> species. Only 1.6% of the cases were infected by <i>Streptococcus pneumonia</i>, <i>Haemophilus influenzae</i>, <i>Salmonella typhi</i> and <i>Klebsiella</i>. In contrast, children without sepsis presented positive blood cultures with growth of <i>Salmonella typhi</i> in 2.4% of the cases and growth of <i>Klebsiella</i> in 1.2%. Bacteria were sensitive to imipenem in 100% of the cases (86% for meropenem, 83% for ceftazidime and 76% for ciprofloxacin). The mortality rate was significantly higher in children with pneumonia complicated by sepsis (odds ratio (OR) = 3.02, 95% confidence interval (CI), 1.11–8.64, <i>p</i> < 0.027). Knowledge about specific laboratory characteristics in children with pneumonia will facilitate an early diagnosis and treatment of sepsis and reduce mortality.https://www.mdpi.com/2075-1729/11/5/450bacterial resistancechildrenmortalitypneumoniasepsis |
spellingShingle | Sufia Islam Ashiqur Rahman Akand Tasnova Tasnim Nova Christian Lehmann Mohammod Jobayer Chisti Sensitivity Patterns of Bacterial Pathogens Isolated from Blood Cultures of Under-Five Children with Pneumonia and Clinical Sepsis Life bacterial resistance children mortality pneumonia sepsis |
title | Sensitivity Patterns of Bacterial Pathogens Isolated from Blood Cultures of Under-Five Children with Pneumonia and Clinical Sepsis |
title_full | Sensitivity Patterns of Bacterial Pathogens Isolated from Blood Cultures of Under-Five Children with Pneumonia and Clinical Sepsis |
title_fullStr | Sensitivity Patterns of Bacterial Pathogens Isolated from Blood Cultures of Under-Five Children with Pneumonia and Clinical Sepsis |
title_full_unstemmed | Sensitivity Patterns of Bacterial Pathogens Isolated from Blood Cultures of Under-Five Children with Pneumonia and Clinical Sepsis |
title_short | Sensitivity Patterns of Bacterial Pathogens Isolated from Blood Cultures of Under-Five Children with Pneumonia and Clinical Sepsis |
title_sort | sensitivity patterns of bacterial pathogens isolated from blood cultures of under five children with pneumonia and clinical sepsis |
topic | bacterial resistance children mortality pneumonia sepsis |
url | https://www.mdpi.com/2075-1729/11/5/450 |
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