Signal transduction interfaces for field-effect transistor-based biosensors
Abstract Biosensors based on field-effect transistors (FETs) are suitable for use in miniaturized and cost-effective healthcare devices. Various semiconductive materials can be applied as FET channels for biosensing, including one- and two-dimensional materials. The signal transduction interface bet...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Communications Chemistry |
| Online Access: | https://doi.org/10.1038/s42004-024-01121-6 |
| _version_ | 1797275548901179392 |
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| author | Toshiya Sakata |
| author_facet | Toshiya Sakata |
| author_sort | Toshiya Sakata |
| collection | DOAJ |
| description | Abstract Biosensors based on field-effect transistors (FETs) are suitable for use in miniaturized and cost-effective healthcare devices. Various semiconductive materials can be applied as FET channels for biosensing, including one- and two-dimensional materials. The signal transduction interface between the biosample and the channel of FETs plays a key role in translating electrochemical reactions into output signals, thereby capturing target ions or biomolecules. In this Review, distinctive signal transduction interfaces for FET biosensors are introduced, categorized as chemically synthesized, physically structured, and biologically induced interfaces. The Review highlights that these signal transduction interfaces are key in controlling biosensing parameters, such as specificity, selectivity, binding constant, limit of detection, signal-to-noise ratio, and biocompatibility. |
| first_indexed | 2024-03-07T15:16:03Z |
| format | Article |
| id | doaj.art-5f97e4169c2c4f738f72798d1558b8a9 |
| institution | Directory Open Access Journal |
| issn | 2399-3669 |
| language | English |
| last_indexed | 2024-03-07T15:16:03Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Chemistry |
| spelling | doaj.art-5f97e4169c2c4f738f72798d1558b8a92024-03-05T17:55:26ZengNature PortfolioCommunications Chemistry2399-36692024-02-017111410.1038/s42004-024-01121-6Signal transduction interfaces for field-effect transistor-based biosensorsToshiya Sakata0Department of Materials Engineering, School of Engineering, The University of TokyoAbstract Biosensors based on field-effect transistors (FETs) are suitable for use in miniaturized and cost-effective healthcare devices. Various semiconductive materials can be applied as FET channels for biosensing, including one- and two-dimensional materials. The signal transduction interface between the biosample and the channel of FETs plays a key role in translating electrochemical reactions into output signals, thereby capturing target ions or biomolecules. In this Review, distinctive signal transduction interfaces for FET biosensors are introduced, categorized as chemically synthesized, physically structured, and biologically induced interfaces. The Review highlights that these signal transduction interfaces are key in controlling biosensing parameters, such as specificity, selectivity, binding constant, limit of detection, signal-to-noise ratio, and biocompatibility.https://doi.org/10.1038/s42004-024-01121-6 |
| spellingShingle | Toshiya Sakata Signal transduction interfaces for field-effect transistor-based biosensors Communications Chemistry |
| title | Signal transduction interfaces for field-effect transistor-based biosensors |
| title_full | Signal transduction interfaces for field-effect transistor-based biosensors |
| title_fullStr | Signal transduction interfaces for field-effect transistor-based biosensors |
| title_full_unstemmed | Signal transduction interfaces for field-effect transistor-based biosensors |
| title_short | Signal transduction interfaces for field-effect transistor-based biosensors |
| title_sort | signal transduction interfaces for field effect transistor based biosensors |
| url | https://doi.org/10.1038/s42004-024-01121-6 |
| work_keys_str_mv | AT toshiyasakata signaltransductioninterfacesforfieldeffecttransistorbasedbiosensors |