An Unusual Presentation of Tuberculosis in a Crohn’s Disease Patient Treated With Anti-TNF
In view of the increase in the therapeutic arsenal available for the treatment of inflammatory bowel disease in recent years, concerns about safety and side effects of immunosuppressive therapies have been increasingly common in clinical practice. The combination of thiopurines and anti-tumor necros...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Gastro Hep Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572322000796 |
| _version_ | 1811274032968892416 |
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| author | Luísa Leite Barros Alexandre de Sousa Carlos Matheus Freitas Cardoso de Azevedo |
| author_facet | Luísa Leite Barros Alexandre de Sousa Carlos Matheus Freitas Cardoso de Azevedo |
| author_sort | Luísa Leite Barros |
| collection | DOAJ |
| description | In view of the increase in the therapeutic arsenal available for the treatment of inflammatory bowel disease in recent years, concerns about safety and side effects of immunosuppressive therapies have been increasingly common in clinical practice. The combination of thiopurines and anti-tumor necrosis factor agents exposes patients to greater risks of serious and opportunistic infection such as tuberculosis (TB). Here we report a case of a 38-year-old female with an 8-year history of a fistulizing ileocolonic and perianal Crohn’s disease that developed TB on the tongue and disseminated during treatment with adalimumab and azathioprine. TB remains a global public health problem characterized by high morbidity and mortality worldwide. The reported case draws attention to an extremely unusual presentation of TB involving the tongue. TB should be included in the differential diagnosis of oral lesions in patients with inflammatory bowel disease, especially in endemic areas. |
| first_indexed | 2024-04-12T23:10:29Z |
| format | Article |
| id | doaj.art-5f97fd8eb33847f38e92d87cc803aaad |
| institution | Directory Open Access Journal |
| issn | 2772-5723 |
| language | English |
| last_indexed | 2024-04-12T23:10:29Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj.art-5f97fd8eb33847f38e92d87cc803aaad2022-12-22T03:12:48ZengElsevierGastro Hep Advances2772-57232022-01-0115792793An Unusual Presentation of Tuberculosis in a Crohn’s Disease Patient Treated With Anti-TNFLuísa Leite Barros0Alexandre de Sousa Carlos1Matheus Freitas Cardoso de Azevedo2Correspondence: Address correspondence to: Luísa Leite Barros, MD, Department of Gastroenterology, Hospital das Clínicas, University of São Paulo School of Medicine, 255, Dr Eneas de Carvalho Aguiar Av, São Paulo, SP 05403000, Brazil.; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, BrazilDepartment of Gastroenterology, University of São Paulo School of Medicine, São Paulo, BrazilDepartment of Gastroenterology, University of São Paulo School of Medicine, São Paulo, BrazilIn view of the increase in the therapeutic arsenal available for the treatment of inflammatory bowel disease in recent years, concerns about safety and side effects of immunosuppressive therapies have been increasingly common in clinical practice. The combination of thiopurines and anti-tumor necrosis factor agents exposes patients to greater risks of serious and opportunistic infection such as tuberculosis (TB). Here we report a case of a 38-year-old female with an 8-year history of a fistulizing ileocolonic and perianal Crohn’s disease that developed TB on the tongue and disseminated during treatment with adalimumab and azathioprine. TB remains a global public health problem characterized by high morbidity and mortality worldwide. The reported case draws attention to an extremely unusual presentation of TB involving the tongue. TB should be included in the differential diagnosis of oral lesions in patients with inflammatory bowel disease, especially in endemic areas.http://www.sciencedirect.com/science/article/pii/S2772572322000796Crohn’s DiseaseTuberculosisAnti-TNF |
| spellingShingle | Luísa Leite Barros Alexandre de Sousa Carlos Matheus Freitas Cardoso de Azevedo An Unusual Presentation of Tuberculosis in a Crohn’s Disease Patient Treated With Anti-TNF Gastro Hep Advances Crohn’s Disease Tuberculosis Anti-TNF |
| title | An Unusual Presentation of Tuberculosis in a Crohn’s Disease Patient Treated With Anti-TNF |
| title_full | An Unusual Presentation of Tuberculosis in a Crohn’s Disease Patient Treated With Anti-TNF |
| title_fullStr | An Unusual Presentation of Tuberculosis in a Crohn’s Disease Patient Treated With Anti-TNF |
| title_full_unstemmed | An Unusual Presentation of Tuberculosis in a Crohn’s Disease Patient Treated With Anti-TNF |
| title_short | An Unusual Presentation of Tuberculosis in a Crohn’s Disease Patient Treated With Anti-TNF |
| title_sort | unusual presentation of tuberculosis in a crohn s disease patient treated with anti tnf |
| topic | Crohn’s Disease Tuberculosis Anti-TNF |
| url | http://www.sciencedirect.com/science/article/pii/S2772572322000796 |
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