Volume alterations of brainstem subregions in migraine with aura
Background: The brainstem plays a significant role in migraine pathogenesis, but a relationship between volume alterations of brainstem subregions and migraine aura characteristics has not been sufficiently investigated. The aim of this study is to compare the volume of the brainstem, and its subreg...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158219300646 |
| _version_ | 1818422865474617344 |
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| author | Igor Petrusic Marko Dakovic Jasna Zidverc-Trajkovic |
| author_facet | Igor Petrusic Marko Dakovic Jasna Zidverc-Trajkovic |
| author_sort | Igor Petrusic |
| collection | DOAJ |
| description | Background: The brainstem plays a significant role in migraine pathogenesis, but a relationship between volume alterations of brainstem subregions and migraine aura characteristics has not been sufficiently investigated. The aim of this study is to compare the volume of the brainstem, and its subregions, between patients with a migraine with aura (MwA) and healthy controls (HC), and also to correlate characteristics of MwA and the volume of the brainstem subregions. Methods: Forty-two MwA and 42 HCs, balanced by sex and age, were selected for this study. Total brainstem volume changes as well as volume changes in the pons, medulla, midbrain and the superior cerebellar peduncles were investigated in MwA relative to HCs. In addition, the relationships between brainstem subregions and aura characteristics (aura duration, the frequency of the aura, occurrence of somatosensory and dysphasic aura, duration of a headache, intensity of headache pain and disease duration) were explored in MwA. Results: MwA patients had a larger brainstem volume relative to HCs (25,941.35 ± 2559.2 mm3 vs. 25,179.32 ± 2019.1 mm3; p = .008), as well as the midbrain and pons (6155.98 ± 565.7 mm3 vs. 5964.22 ± 457.0 mm3, p = .002; 15,105.13 ± 1765.5 mm3 vs. 14,539.89 ± 1408.4 mm3, p = .007, respectively). Total brainstem volume, as well as volumes of brainstem subregions, were not significantly correlated to the MwA characteristics. Conclusion: The results of this study reveal that a migraine with aura is associated with a larger volume of the brainstem with a particular involvement of the midbrain and pons. Keywords: Migraine with aura, Brainstem, Midbrain, Pons |
| first_indexed | 2024-12-14T13:33:03Z |
| format | Article |
| id | doaj.art-5f998fe115f040e888c6c54f9305266e |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-14T13:33:03Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-5f998fe115f040e888c6c54f9305266e2022-12-21T22:59:39ZengElsevierNeuroImage: Clinical2213-15822019-01-0122Volume alterations of brainstem subregions in migraine with auraIgor Petrusic0Marko Dakovic1Jasna Zidverc-Trajkovic2Laboratory for advanced analysis of neuroimages, Faculty of Physical Chemistry, University of Belgrade, Serbia; Corresponding author at: Faculty of Physical Chemistry, University of Belgrade, 12-16 Studentski Trg Street, 11000 Belgrade, Serbia.Laboratory for advanced analysis of neuroimages, Faculty of Physical Chemistry, University of Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Serbia; Center for Headaches, Neurology Clinic, Clinical Center of Serbia, SerbiaBackground: The brainstem plays a significant role in migraine pathogenesis, but a relationship between volume alterations of brainstem subregions and migraine aura characteristics has not been sufficiently investigated. The aim of this study is to compare the volume of the brainstem, and its subregions, between patients with a migraine with aura (MwA) and healthy controls (HC), and also to correlate characteristics of MwA and the volume of the brainstem subregions. Methods: Forty-two MwA and 42 HCs, balanced by sex and age, were selected for this study. Total brainstem volume changes as well as volume changes in the pons, medulla, midbrain and the superior cerebellar peduncles were investigated in MwA relative to HCs. In addition, the relationships between brainstem subregions and aura characteristics (aura duration, the frequency of the aura, occurrence of somatosensory and dysphasic aura, duration of a headache, intensity of headache pain and disease duration) were explored in MwA. Results: MwA patients had a larger brainstem volume relative to HCs (25,941.35 ± 2559.2 mm3 vs. 25,179.32 ± 2019.1 mm3; p = .008), as well as the midbrain and pons (6155.98 ± 565.7 mm3 vs. 5964.22 ± 457.0 mm3, p = .002; 15,105.13 ± 1765.5 mm3 vs. 14,539.89 ± 1408.4 mm3, p = .007, respectively). Total brainstem volume, as well as volumes of brainstem subregions, were not significantly correlated to the MwA characteristics. Conclusion: The results of this study reveal that a migraine with aura is associated with a larger volume of the brainstem with a particular involvement of the midbrain and pons. Keywords: Migraine with aura, Brainstem, Midbrain, Ponshttp://www.sciencedirect.com/science/article/pii/S2213158219300646 |
| spellingShingle | Igor Petrusic Marko Dakovic Jasna Zidverc-Trajkovic Volume alterations of brainstem subregions in migraine with aura NeuroImage: Clinical |
| title | Volume alterations of brainstem subregions in migraine with aura |
| title_full | Volume alterations of brainstem subregions in migraine with aura |
| title_fullStr | Volume alterations of brainstem subregions in migraine with aura |
| title_full_unstemmed | Volume alterations of brainstem subregions in migraine with aura |
| title_short | Volume alterations of brainstem subregions in migraine with aura |
| title_sort | volume alterations of brainstem subregions in migraine with aura |
| url | http://www.sciencedirect.com/science/article/pii/S2213158219300646 |
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