Effects of poly (ADP-ribose) polymerase-1 (PARP-1) inhibition on sulfur mustard-induced cutaneous injuries in vitro and in vivo

Effects of poly (ADP-ribose) polymerase-1 (PARP-1) inhibition on sulfur mustard-induced cutaneous injuries in vitro and in vivo

Early studies with first-generation poly (ADP-ribose) polymerase (PARP) inhibitors have already indicated some therapeutic potential for sulfur mustard (SM) injuries. The available novel and more potential PARP inhibitors, which are undergoing clinical trials as drugs for cancer treatment, bring it...

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Bibliographic Details
Main Authors: Feng Liu, Ning Jiang, Zhi-yong Xiao, Jun-ping Cheng, Yi-zhou Mei, Pan Zheng, Li Wang, Xiao-rui Zhang, Xin-bo Zhou, Wen-xia Zhou, Yong-xiang Zhang
Format: Article
Language:English
Published: PeerJ Inc. 2016-04-01
Series:PeerJ
Subjects:
Sulfur mustard
PARP-1
DNA damage
NAD+
Apoptosis
Necrosis
Online Access:https://peerj.com/articles/1890.pdf

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