The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017
Abstract Hand, foot, and mouth disease (HFMD) is endemic in the Pacific region, especially in mainland China. The case-fatality ratio of HFMD is increasing steadily. Knowledge of the changing epidemiology of HFMD in different regions is necessary for implementing appropriate intervention strategies....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-019-48259-1 |
| _version_ | 1818995066915520512 |
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| author | Jun Qiu Haipeng Yan Nianci Cheng Xiulan Lu Xia Hu Lijuan Liang Zhenghui Xiao Lihong Tan |
| author_facet | Jun Qiu Haipeng Yan Nianci Cheng Xiulan Lu Xia Hu Lijuan Liang Zhenghui Xiao Lihong Tan |
| author_sort | Jun Qiu |
| collection | DOAJ |
| description | Abstract Hand, foot, and mouth disease (HFMD) is endemic in the Pacific region, especially in mainland China. The case-fatality ratio of HFMD is increasing steadily. Knowledge of the changing epidemiology of HFMD in different regions is necessary for implementing appropriate intervention strategies. In this study, we describe the clinical and epidemiological characteristics of HFMD in Hunan Children’s Hospital between 2013 and 2017. A total of 7203 patients with HFMD were admitted, with complication and mortality rates of 35.62% and 0.78%, respectively. The total number of children with HFMD, proportion of severely ill children, and HFMD mortality rate were the highest in 2014. The number of cases caused by EV-A71 and CV-A16 decreased continuously, while the number of cases caused by ‘other enteroviruses’ increased yearly since 2014, suggesting that other enteric viruses will gradually replace EV-A71 and CV-A16 as the main pathogenic HFMD agents. Furthermore, EV-A71 and mixed infections accounted for the high case fatality rates in children with severe HFMD, among whom EV-A71 infection resulted in the highest complication and mortality rates; the mild form of the disease was dominated by ‘other enteroviruses’. In conclusion, the changing etiological pattern highlights the need to improve pathogen surveillance and vaccine strategies for HFMD control. |
| first_indexed | 2024-12-20T21:07:56Z |
| format | Article |
| id | doaj.art-5f9b5dbfa9554e3ca5380d2f25187eef |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T21:07:56Z |
| publishDate | 2019-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-5f9b5dbfa9554e3ca5380d2f25187eef2022-12-21T19:26:34ZengNature PortfolioScientific Reports2045-23222019-08-01911710.1038/s41598-019-48259-1The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017Jun Qiu0Haipeng Yan1Nianci Cheng2Xiulan Lu3Xia Hu4Lijuan Liang5Zhenghui Xiao6Lihong Tan7House of Journal of Clinical Pediatric Surgery, Hunan Children’s Hospital, University of South ChinaDepartment of Pediatric Intensive Care Unit (PICU), Hunan Children’s Hospital, University of South ChinaDepartment of Pediatric Intensive Care Unit (PICU), Hunan Children’s Hospital, University of South ChinaDepartment of Pediatric Intensive Care Unit (PICU), Hunan Children’s Hospital, University of South ChinaDepartment of Pediatric Intensive Care Unit (PICU), Hunan Children’s Hospital, University of South ChinaDepartment of Pediatric Intensive Care Unit (PICU), Hunan Children’s Hospital, University of South ChinaDepartment of Pediatric Intensive Care Unit (PICU), Hunan Children’s Hospital, University of South ChinaHouse of Journal of Clinical Pediatric Surgery, Hunan Children’s Hospital, University of South ChinaAbstract Hand, foot, and mouth disease (HFMD) is endemic in the Pacific region, especially in mainland China. The case-fatality ratio of HFMD is increasing steadily. Knowledge of the changing epidemiology of HFMD in different regions is necessary for implementing appropriate intervention strategies. In this study, we describe the clinical and epidemiological characteristics of HFMD in Hunan Children’s Hospital between 2013 and 2017. A total of 7203 patients with HFMD were admitted, with complication and mortality rates of 35.62% and 0.78%, respectively. The total number of children with HFMD, proportion of severely ill children, and HFMD mortality rate were the highest in 2014. The number of cases caused by EV-A71 and CV-A16 decreased continuously, while the number of cases caused by ‘other enteroviruses’ increased yearly since 2014, suggesting that other enteric viruses will gradually replace EV-A71 and CV-A16 as the main pathogenic HFMD agents. Furthermore, EV-A71 and mixed infections accounted for the high case fatality rates in children with severe HFMD, among whom EV-A71 infection resulted in the highest complication and mortality rates; the mild form of the disease was dominated by ‘other enteroviruses’. In conclusion, the changing etiological pattern highlights the need to improve pathogen surveillance and vaccine strategies for HFMD control.https://doi.org/10.1038/s41598-019-48259-1 |
| spellingShingle | Jun Qiu Haipeng Yan Nianci Cheng Xiulan Lu Xia Hu Lijuan Liang Zhenghui Xiao Lihong Tan The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017 Scientific Reports |
| title | The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017 |
| title_full | The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017 |
| title_fullStr | The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017 |
| title_full_unstemmed | The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017 |
| title_short | The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017 |
| title_sort | clinical and epidemiological study of children with hand foot and mouth disease in hunan china from 2013 to 2017 |
| url | https://doi.org/10.1038/s41598-019-48259-1 |
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