DOPAMINE AND THE BIOLOGY OF CREATIVITY: LESSONS FROM PARKINSON’S DISEASE
BACKGROUND: Parkinson’s disease (PD) is characterized by reduced flexibility, conceptualization and visuo-spatial abilities. Although these are essential to creativity, case studies show emergence of creativity during PD. Knowledge about the role of dopamine in creativity so far only stems from a fe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00055/full |
| _version_ | 1818014616736759808 |
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| author | Eugénie eLhommée Eugénie eLhommée Alina eBatir Jean-Louis eQuesada Claire eArdouin Valérie eFraix Valérie eFraix Eric eSeigneuret Stéphan eChabardès Stéphan eChabardès Alim-Louis eBenabid Pierre ePollak Paul eKrack Paul eKrack |
| author_facet | Eugénie eLhommée Eugénie eLhommée Alina eBatir Jean-Louis eQuesada Claire eArdouin Valérie eFraix Valérie eFraix Eric eSeigneuret Stéphan eChabardès Stéphan eChabardès Alim-Louis eBenabid Pierre ePollak Paul eKrack Paul eKrack |
| author_sort | Eugénie eLhommée |
| collection | DOAJ |
| description | BACKGROUND: Parkinson’s disease (PD) is characterized by reduced flexibility, conceptualization and visuo-spatial abilities. Although these are essential to creativity, case studies show emergence of creativity during PD. Knowledge about the role of dopamine in creativity so far only stems from a few case reports. We aim at demonstrating that creativity can be induced by dopaminergic treatments in PD, and tends to disappear after withdrawal of dopamine agonists. <br/>METHODS: 11 consecutive creative PD patients were selected from candidates for subthalamic deep brain stimulation (STN DBS) surgery, and compared to 22 non-creative control PD patients. Motor disability (UPDRS III), cognition (Frontal Score, Mattis scale) and behaviour (Ardouin scale) were assessed before surgery and one year after. <br/>RESULTS: Before surgery, whereas cognitive and motor assessments where similar between groups, dopamine agonist (but not levodopa) dosages were higher in creative patients (p=0.01). The Ardouin scale revealed also a specific psycho-behavioural profile of creative patients which had higher scores for mania (p< 0.001), hobbyism (p=0.001), nocturnal hyperactivity (p=0.041), appetitive functioning (p=0.003) and ON euphoria (p=0.007) and lower scores for apathy and OFF dysphoria (p=0.04 for each). Postoperative motor, cognitive and behavioural scores as dopaminergic treatment dosages were equivalent between groups. Motor improvement allowed for a 68.6% decrease in dopaminergic treatment. Only one of the 11 patients remained creative after surgery. Reduction of dopamine agonist was significantly correlated to the decrease in creativity in the whole population of study (Spearman correlation coefficient ρ =0.47 with confidence index of 95% = [0.16;0.70], p=0.0053). <br/>CONCLUSION: Creativity in PD is linked to dopamine agonist therapy, and tends to disappear after STN DBS in parallel to reduction of dopamine agonists, which are relatively selective for the mesolimbic D3 dopamine receptors |
| first_indexed | 2024-04-14T06:46:31Z |
| format | Article |
| id | doaj.art-5f9cd348dfba479fbbad17dc384c6d1b |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-14T06:46:31Z |
| publishDate | 2014-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-5f9cd348dfba479fbbad17dc384c6d1b2022-12-22T02:07:09ZengFrontiers Media S.A.Frontiers in Neurology1664-22952014-04-01510.3389/fneur.2014.0005581677DOPAMINE AND THE BIOLOGY OF CREATIVITY: LESSONS FROM PARKINSON’S DISEASEEugénie eLhommée0Eugénie eLhommée1Alina eBatir2Jean-Louis eQuesada3Claire eArdouin4Valérie eFraix5Valérie eFraix6Eric eSeigneuret7Stéphan eChabardès8Stéphan eChabardès9Alim-Louis eBenabid10Pierre ePollak11Paul eKrack12Paul eKrack13Grenoble University Hospital - Movement disorders UnitINSERM, Unité 836, Grenoble Institut des NeurosciencesGrenoble University Hospital - Movement disorders UnitCHU Grenoble, Université Joseph FourierGrenoble University Hospital - Movement disorders UnitGrenoble University Hospital - Movement disorders UnitINSERM, Unité 836, Grenoble Institut des NeurosciencesGrenoble University HospitalINSERM, Unité 836, Grenoble Institut des NeurosciencesGrenoble University HospitalClinatec, DRT/LETI, CEA-GrenobleGeneva University HospitalGrenoble University Hospital - Movement disorders UnitINSERM, Unité 836, Grenoble Institut des NeurosciencesBACKGROUND: Parkinson’s disease (PD) is characterized by reduced flexibility, conceptualization and visuo-spatial abilities. Although these are essential to creativity, case studies show emergence of creativity during PD. Knowledge about the role of dopamine in creativity so far only stems from a few case reports. We aim at demonstrating that creativity can be induced by dopaminergic treatments in PD, and tends to disappear after withdrawal of dopamine agonists. <br/>METHODS: 11 consecutive creative PD patients were selected from candidates for subthalamic deep brain stimulation (STN DBS) surgery, and compared to 22 non-creative control PD patients. Motor disability (UPDRS III), cognition (Frontal Score, Mattis scale) and behaviour (Ardouin scale) were assessed before surgery and one year after. <br/>RESULTS: Before surgery, whereas cognitive and motor assessments where similar between groups, dopamine agonist (but not levodopa) dosages were higher in creative patients (p=0.01). The Ardouin scale revealed also a specific psycho-behavioural profile of creative patients which had higher scores for mania (p< 0.001), hobbyism (p=0.001), nocturnal hyperactivity (p=0.041), appetitive functioning (p=0.003) and ON euphoria (p=0.007) and lower scores for apathy and OFF dysphoria (p=0.04 for each). Postoperative motor, cognitive and behavioural scores as dopaminergic treatment dosages were equivalent between groups. Motor improvement allowed for a 68.6% decrease in dopaminergic treatment. Only one of the 11 patients remained creative after surgery. Reduction of dopamine agonist was significantly correlated to the decrease in creativity in the whole population of study (Spearman correlation coefficient ρ =0.47 with confidence index of 95% = [0.16;0.70], p=0.0053). <br/>CONCLUSION: Creativity in PD is linked to dopamine agonist therapy, and tends to disappear after STN DBS in parallel to reduction of dopamine agonists, which are relatively selective for the mesolimbic D3 dopamine receptorshttp://journal.frontiersin.org/Journal/10.3389/fneur.2014.00055/fullDopamineImpulse Control DisorderscreativityParkinson's diseaseSTN-DBS |
| spellingShingle | Eugénie eLhommée Eugénie eLhommée Alina eBatir Jean-Louis eQuesada Claire eArdouin Valérie eFraix Valérie eFraix Eric eSeigneuret Stéphan eChabardès Stéphan eChabardès Alim-Louis eBenabid Pierre ePollak Paul eKrack Paul eKrack DOPAMINE AND THE BIOLOGY OF CREATIVITY: LESSONS FROM PARKINSON’S DISEASE Frontiers in Neurology Dopamine Impulse Control Disorders creativity Parkinson's disease STN-DBS |
| title | DOPAMINE AND THE BIOLOGY OF CREATIVITY: LESSONS FROM PARKINSON’S DISEASE |
| title_full | DOPAMINE AND THE BIOLOGY OF CREATIVITY: LESSONS FROM PARKINSON’S DISEASE |
| title_fullStr | DOPAMINE AND THE BIOLOGY OF CREATIVITY: LESSONS FROM PARKINSON’S DISEASE |
| title_full_unstemmed | DOPAMINE AND THE BIOLOGY OF CREATIVITY: LESSONS FROM PARKINSON’S DISEASE |
| title_short | DOPAMINE AND THE BIOLOGY OF CREATIVITY: LESSONS FROM PARKINSON’S DISEASE |
| title_sort | dopamine and the biology of creativity lessons from parkinson s disease |
| topic | Dopamine Impulse Control Disorders creativity Parkinson's disease STN-DBS |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00055/full |
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