In Vitro Efficacy and Molecular Mechanism of Curcumin Analog in Pathological Regulation of Spinocerebellar Ataxia Type 3

In Vitro Efficacy and Molecular Mechanism of Curcumin Analog in Pathological Regulation of Spinocerebellar Ataxia Type 3

Unlike other nuclear factor erythroid-2-related factor 2 (Nrf2) activators, the mechanism of action of curcumin analog, ASC-JM17 (JM17), in regulating oxidative homeostasis remains unknown. Spinocerebellar ataxia type 3 (SCA3) is an inherited polyglutamine neurodegenerative disease caused mainly by...

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Bibliographic Details
Main Authors: Yu-Ling Wu, Jui-Chih Chang, Yi-Chun Chao, Hardy Chan, Mingli Hsieh, Chin-San Liu
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antioxidants
Subjects:
spinocerebellar ataxia type 3
curcumin analog
nuclear factor erythroid-2 related factor 2
anti-oxidative enzymes
mitochondrial function
Online Access:https://www.mdpi.com/2076-3921/11/7/1389

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