EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES
<p>Review of clinical studies on the use of ethylmethylhydroxypyridine succinate (EMHPS) medications in patients with stroke and its consequences is presented. EMHPS drugs are widely used in routine clinical practice in Russia, despite the absence of clear evidence of neuroprotection in stroke...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Столичная издательская компания
2015-09-01
|
| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | http://www.rpcardio.ru/jour/article/view/194 |
| _version_ | 1797728201124872192 |
|---|---|
| author | A. D. Ehrlikh N. A. Gratsianskii |
| author_facet | A. D. Ehrlikh N. A. Gratsianskii |
| author_sort | A. D. Ehrlikh |
| collection | DOAJ |
| description | <p>Review of clinical studies on the use of ethylmethylhydroxypyridine succinate (EMHPS) medications in patients with stroke and its consequences is presented. EMHPS drugs are widely used in routine clinical practice in Russia, despite the absence of clear evidence of neuroprotection in stroke. Most clinical studies of EMHPS drugs were small, nonrandomized and had "soft" endpoints. The results in many papers are presented without appropriate statistical comparisons. In many studies of EMHPS drugs different administration regimens were used that are often not described in the drug instructions and the federal guidelines. Correlation between EMHPS use and decreasing mortality after stroke was not shown in any of the studies. Existing studies have not provided compelling evidence for widespread clinical use of EMHPS drugs in patients with stroke and its consequences.</p> |
| first_indexed | 2024-03-12T11:10:37Z |
| format | Article |
| id | doaj.art-5f9e8a953c294f428d40f82e8c705186 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-03-12T11:10:37Z |
| publishDate | 2015-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-5f9e8a953c294f428d40f82e8c7051862023-09-02T02:59:44ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-09-0110444845610.1234/1819-6446-2014-4-448-456194EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCESA. D. Ehrlikh0N. A. Gratsianskii1Научно исследовательский институт физико-химической медицины Федерального медико-биологического агентства РоссииНаучно исследовательский институт физико-химической медицины Федерального медико-биологического агентства России<p>Review of clinical studies on the use of ethylmethylhydroxypyridine succinate (EMHPS) medications in patients with stroke and its consequences is presented. EMHPS drugs are widely used in routine clinical practice in Russia, despite the absence of clear evidence of neuroprotection in stroke. Most clinical studies of EMHPS drugs were small, nonrandomized and had "soft" endpoints. The results in many papers are presented without appropriate statistical comparisons. In many studies of EMHPS drugs different administration regimens were used that are often not described in the drug instructions and the federal guidelines. Correlation between EMHPS use and decreasing mortality after stroke was not shown in any of the studies. Existing studies have not provided compelling evidence for widespread clinical use of EMHPS drugs in patients with stroke and its consequences.</p>http://www.rpcardio.ru/jour/article/view/194этилметилгидроксипиридина сукцинатинсультисследования |
| spellingShingle | A. D. Ehrlikh N. A. Gratsianskii EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES Рациональная фармакотерапия в кардиологии этилметилгидроксипиридина сукцинат инсульт исследования |
| title | EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES |
| title_full | EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES |
| title_fullStr | EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES |
| title_full_unstemmed | EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES |
| title_short | EVIDENCE BASE OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE USE IN PATIENTS WITH STROKE AND ITS CONSEQUENCES |
| title_sort | evidence base of ethylmethylhydroxypyridine succinate use in patients with stroke and its consequences |
| topic | этилметилгидроксипиридина сукцинат инсульт исследования |
| url | http://www.rpcardio.ru/jour/article/view/194 |
| work_keys_str_mv | AT adehrlikh evidencebaseofethylmethylhydroxypyridinesuccinateuseinpatientswithstrokeanditsconsequences AT nagratsianskii evidencebaseofethylmethylhydroxypyridinesuccinateuseinpatientswithstrokeanditsconsequences |