Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality
Over the past decades, research attention has increasingly been paid to the neurobiological component of sexual behavior. The aim of the present study was to investigate the correlation of estrogen receptor α (ERA) gene polymorphism (rs2234693-PvuII) (T→C substitution) and oxytocin receptor gene pol...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2017-02-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | http://www.endocrineconnections.com/content/6/1/44.full |
| _version_ | 1818891230653710336 |
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| author | Anastasia K Armeni Konstantinos Assimakopoulos Dimitra Marioli Vassiliki Koika Euthychia Michaelidou Niki Mourtzi Gregoris Iconomou Neoklis A Georgopoulos |
| author_facet | Anastasia K Armeni Konstantinos Assimakopoulos Dimitra Marioli Vassiliki Koika Euthychia Michaelidou Niki Mourtzi Gregoris Iconomou Neoklis A Georgopoulos |
| author_sort | Anastasia K Armeni |
| collection | DOAJ |
| description | Over the past decades, research attention has increasingly been paid to the neurobiological component of sexual behavior. The aim of the present study was to investigate the correlation of estrogen receptor α (ERA) gene polymorphism (rs2234693-PvuII) (T→C substitution) and oxytocin receptor gene polymorphism
(rs53576) (G→A substitution) with sexuality parameters of young, healthy women. One hundred thirty-three Greek heterosexual women, students in higher education institutions, 20–25 years of age, sexually active, with normal menstrual cycles
(28–35 days), were recruited in the study. Exclusion criteria were chronic and/or major psychiatric diseases, use of oral contraceptive pills (OCs), polycystic ovary syndrome (PCOS), thyroid diseases as well as drugs that are implicated in hypothalamus–pituitary–gonadal axis. T allele (wildtype) of rs2234693 (PvuII) polymorphism of ERA gene was correlated with increased levels of arousal and lubrication, whereas A allele (polymorphic) of rs53576 (OXTR) polymorphism was correlated with increased arousal levels. The simultaneous presence of both T allele of rs2234693 (PvuII) and A allele of rs53576 (OXTR) polymorphisms (T + A group) was correlated with increased arousal, orgasm levels as well as female sexual function index full score. To our knowledge, this is the first study to investigate the interaction between ERA and OXTR with regard to sexual function in women. Female sexuality is a complex behavioral trait that encompasses both biological and psychological components. It seems that variability in female sexual response stems from genetic variability that characterizes endocrine, neurotransmitter and central nervous system influences. |
| first_indexed | 2024-12-19T17:37:30Z |
| format | Article |
| id | doaj.art-5f9fdcecd26342e68c2699b7c598b057 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-19T17:37:30Z |
| publishDate | 2017-02-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-5f9fdcecd26342e68c2699b7c598b0572022-12-21T20:12:17ZengBioscientificaEndocrine Connections2049-36142049-36142017-02-0161445210.1530/EC-16-0090Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexualityAnastasia K Armeni0Konstantinos Assimakopoulos1Dimitra Marioli2Vassiliki Koika3Euthychia Michaelidou4Niki Mourtzi5Gregoris Iconomou6Neoklis A Georgopoulos7Division of Reproductive Endocrinology, Department of Obstetrics and Gynaecology, University of Patras Medical School, Patras, GreeceDepartment of Psychiatry, University of Patras Medical School, Patras, GreeceDivision of Reproductive Endocrinology, Department of Obstetrics and Gynaecology, University of Patras Medical School, Patras, GreeceDivision of Reproductive Endocrinology, Department of Obstetrics and Gynaecology, University of Patras Medical School, Patras, GreeceDepartment of Biology, University of Patras, Patras, GreeceDepartment of Biology, University of Patras, Patras, GreeceDepartment of Psychiatry, University of Patras Medical School, Patras, GreeceDivision of Reproductive Endocrinology, Department of Obstetrics and Gynaecology, University of Patras Medical School, Patras, GreeceOver the past decades, research attention has increasingly been paid to the neurobiological component of sexual behavior. The aim of the present study was to investigate the correlation of estrogen receptor α (ERA) gene polymorphism (rs2234693-PvuII) (T→C substitution) and oxytocin receptor gene polymorphism (rs53576) (G→A substitution) with sexuality parameters of young, healthy women. One hundred thirty-three Greek heterosexual women, students in higher education institutions, 20–25 years of age, sexually active, with normal menstrual cycles (28–35 days), were recruited in the study. Exclusion criteria were chronic and/or major psychiatric diseases, use of oral contraceptive pills (OCs), polycystic ovary syndrome (PCOS), thyroid diseases as well as drugs that are implicated in hypothalamus–pituitary–gonadal axis. T allele (wildtype) of rs2234693 (PvuII) polymorphism of ERA gene was correlated with increased levels of arousal and lubrication, whereas A allele (polymorphic) of rs53576 (OXTR) polymorphism was correlated with increased arousal levels. The simultaneous presence of both T allele of rs2234693 (PvuII) and A allele of rs53576 (OXTR) polymorphisms (T + A group) was correlated with increased arousal, orgasm levels as well as female sexual function index full score. To our knowledge, this is the first study to investigate the interaction between ERA and OXTR with regard to sexual function in women. Female sexuality is a complex behavioral trait that encompasses both biological and psychological components. It seems that variability in female sexual response stems from genetic variability that characterizes endocrine, neurotransmitter and central nervous system influences.http://www.endocrineconnections.com/content/6/1/44.fullestrogen receptor α gene polymorphismoxytocin receptor gene polymorphismfemale sexuality |
| spellingShingle | Anastasia K Armeni Konstantinos Assimakopoulos Dimitra Marioli Vassiliki Koika Euthychia Michaelidou Niki Mourtzi Gregoris Iconomou Neoklis A Georgopoulos Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality Endocrine Connections estrogen receptor α gene polymorphism oxytocin receptor gene polymorphism female sexuality |
| title | Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality |
| title_full | Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality |
| title_fullStr | Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality |
| title_full_unstemmed | Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality |
| title_short | Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality |
| title_sort | impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality |
| topic | estrogen receptor α gene polymorphism oxytocin receptor gene polymorphism female sexuality |
| url | http://www.endocrineconnections.com/content/6/1/44.full |
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