Defining the ligand-dependent proximatome of the sigma 1 receptor

Defining the ligand-dependent proximatome of the sigma 1 receptor

Sigma 1 Receptor (S1R) is a therapeutic target for a wide spectrum of pathological conditions ranging from neurodegenerative diseases to cancer and COVID-19. S1R is ubiquitously expressed throughout the visceral organs, nervous, immune and cardiovascular systems. It is proposed to function as a liga...

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Bibliographic Details
Main Authors: Jing Zhao, Rajalakshmi Veeranan-Karmegam, Frederick C. Baker, Barbara A. Mysona, Pritha Bagchi, Yutao Liu, Sylvia B. Smith, Graydon B. Gonsalvez, Kathryn E. Bollinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
molecular chapterone
ERGIC
cholesterol
PCSK9
LDLR
secretome
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1045759/full

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