A Case Report on Zoledronic Acid as Palliative Treatment in Carcinoma of Lung with Bone Metastasis
Bone metastasis is a general complication of advanced carcinomas, usually seen in breast cancer, prostate cancer, non-small cell lung cancer and multiple myeloma. Zoledronic acid, which belongs to bisphosphonates, is indicated for bone metastasis caused due to carcinomas. This case report is about a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2023-07-01
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| Series: | Forum of Clinical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/fco-2023-0001 |
| _version_ | 1797208431933784064 |
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| author | Sandhya Y. Swathi M. Yeshavanth G. Nagaraja V.T. |
| author_facet | Sandhya Y. Swathi M. Yeshavanth G. Nagaraja V.T. |
| author_sort | Sandhya Y. |
| collection | DOAJ |
| description | Bone metastasis is a general complication of advanced carcinomas, usually seen in breast cancer, prostate cancer, non-small cell lung cancer and multiple myeloma. Zoledronic acid, which belongs to bisphosphonates, is indicated for bone metastasis caused due to carcinomas. This case report is about a patient with carcinoma of lung (Stage 4) with bone metastasis who has been provided with zoledronic acid as a palliative treatment. The patient was a 65-year-old male with the known case of type 2 diabetes mellitus (T2DM) and ischemic heart disease (IHD) status post (s/p) coronary artery angiography (CAG) with left ventricular ejection fraction (LVEF) 30% who was on medication. He presented with chest pain and breathlessness nine months prior and his multi-detected computed tomography (MDCT) pulmonary angiography revealed bronchogenic carcinoma. A computed tomography (CT) scan showed a metabolically active lytic lesion involving the left posterior 2nd rib and degenerative changes were noted in the spine. He has now reported upper back pain for three months localised to the left and right inferior scapular region. His pain scored a nine on the Visual Analogue Scale (VAS), and he was prescribed zoledronic acid 5mg/100ml IV infusion once in 3 weeks. On a revisit, the patient was assessed to be symptomatically better, and the pain score was lowered to 6, indicating reduced severity of discomfort. In conclusion, zoledronic acid is effective in the palliative treatment of lung cancer patients with bone metastasis. |
| first_indexed | 2024-04-24T09:38:42Z |
| format | Article |
| id | doaj.art-5fa476525e6b4219962fab775f30b618 |
| institution | Directory Open Access Journal |
| issn | 1792-362X |
| language | English |
| last_indexed | 2024-04-24T09:38:42Z |
| publishDate | 2023-07-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Forum of Clinical Oncology |
| spelling | doaj.art-5fa476525e6b4219962fab775f30b6182024-04-15T07:42:59ZengSciendoForum of Clinical Oncology1792-362X2023-07-01133495110.2478/fco-2023-0001A Case Report on Zoledronic Acid as Palliative Treatment in Carcinoma of Lung with Bone MetastasisSandhya Y.0Swathi M.1Yeshavanth G.2Nagaraja V.T.3Department of pharmacy practice, Bapuji Pharmacy College, Davangere, Karnataka, IndiaDepartment of pharmacy practice, Bapuji Pharmacy College, Davangere, Karnataka, IndiaDepartment of General Medicine, SSIMS and RC, Davangere, KarnatakaDepartment of General Medicine, SSIMS and RC, Davangere, KarnatakaBone metastasis is a general complication of advanced carcinomas, usually seen in breast cancer, prostate cancer, non-small cell lung cancer and multiple myeloma. Zoledronic acid, which belongs to bisphosphonates, is indicated for bone metastasis caused due to carcinomas. This case report is about a patient with carcinoma of lung (Stage 4) with bone metastasis who has been provided with zoledronic acid as a palliative treatment. The patient was a 65-year-old male with the known case of type 2 diabetes mellitus (T2DM) and ischemic heart disease (IHD) status post (s/p) coronary artery angiography (CAG) with left ventricular ejection fraction (LVEF) 30% who was on medication. He presented with chest pain and breathlessness nine months prior and his multi-detected computed tomography (MDCT) pulmonary angiography revealed bronchogenic carcinoma. A computed tomography (CT) scan showed a metabolically active lytic lesion involving the left posterior 2nd rib and degenerative changes were noted in the spine. He has now reported upper back pain for three months localised to the left and right inferior scapular region. His pain scored a nine on the Visual Analogue Scale (VAS), and he was prescribed zoledronic acid 5mg/100ml IV infusion once in 3 weeks. On a revisit, the patient was assessed to be symptomatically better, and the pain score was lowered to 6, indicating reduced severity of discomfort. In conclusion, zoledronic acid is effective in the palliative treatment of lung cancer patients with bone metastasis.https://doi.org/10.2478/fco-2023-0001zoledronic acidpalliative treatmentbone metastasislung cancer |
| spellingShingle | Sandhya Y. Swathi M. Yeshavanth G. Nagaraja V.T. A Case Report on Zoledronic Acid as Palliative Treatment in Carcinoma of Lung with Bone Metastasis Forum of Clinical Oncology zoledronic acid palliative treatment bone metastasis lung cancer |
| title | A Case Report on Zoledronic Acid as Palliative Treatment in Carcinoma of Lung with Bone Metastasis |
| title_full | A Case Report on Zoledronic Acid as Palliative Treatment in Carcinoma of Lung with Bone Metastasis |
| title_fullStr | A Case Report on Zoledronic Acid as Palliative Treatment in Carcinoma of Lung with Bone Metastasis |
| title_full_unstemmed | A Case Report on Zoledronic Acid as Palliative Treatment in Carcinoma of Lung with Bone Metastasis |
| title_short | A Case Report on Zoledronic Acid as Palliative Treatment in Carcinoma of Lung with Bone Metastasis |
| title_sort | case report on zoledronic acid as palliative treatment in carcinoma of lung with bone metastasis |
| topic | zoledronic acid palliative treatment bone metastasis lung cancer |
| url | https://doi.org/10.2478/fco-2023-0001 |
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